Evidence map›Paper›PMID 23826676›Full record

ArticleOrganic letters2013

An efficient synthesis of the fully elaborated isoindolinone unit of muironolide A.

Qing Xiao, Kyle Young, Armen Zakarian

Abstract read
In one paragraph

Article in Organic letters, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Total Synthesis of Allocyclinone A via Late-Stage Halogen Swapping.Angewandte Chemie (International ed. in English) · 2026
    Article
  2. Article
  3. The chemistry of isoindole natural products.Beilstein journal of organic chemistry · 2013
    Review
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Qing XiaoDepartment of Chemistry and Biochemistry, University of California, Santa Barbara, California 93106-9510, USA.
Kyle Young
Armen Zakarian

Funding

Total synthesis of bioactive natural productsR01GM077379 · NIGMS · UNIVERSITY OF CALIFORNIA SANTA BARBARA · PI SERVENT, DENIS, ZAKARIAN, ARMEN · 2008 to 2021
$5.3M
NIGMS NIH HHS R01 GM077379
6 · The paper itself

Abstract

An efficient stereocontrolled construction of the fully substituted isoindolone subunit of muironolide A is described. The approach is centered on the intramolecular Diels-Alder reaction between the enol form of the β-keto amide and an α,β,γ,δ-unsaturated ester, followed by the installation of the cyclohexene double bond.

Indexed as

CatalysisCyclizationCyclohexenesEstersIsoindolesStereoisomerismCyclohexenesEstersIsoindol-1-oneIsoindolesmuironolide A

Identifiers

PMID23826676
PMCPMC3733332

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.