ArticleInternational journal of clinical and experimental pathology2013
Pathologic finding of increased expression of interleukin-17 in the synovial tissue of rheumatoid arthritis patients.
Article in International journal of clinical and experimental pathology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
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Who cites it
25 citing papers in PubMed, 45 citations in OpenAlex.
- Toreforant, an orally active histamine HInflammation research : official journal of the European Histamine Research Society ... [et al.] · 2019Trial
- Pharmacodynamic evaluation and mechanism study of cord blood nucleated cell extract in the treatment of rheumatoid arthritis.Clinical rheumatology · 2026Article
- Ras family signaling pathway in immunopathogenesis of inflammatory rheumatic diseases.Frontiers in immunology · 2023Review
- A Role of IL-17 in Rheumatoid Arthritis Patients Complicated With Atherosclerosis.Frontiers in pharmacology · 2022Review
- Immunomodulatory Function of Vitamin D and Its Role in Autoimmune Thyroid Disease.Frontiers in immunology · 2021Review
- Interleukin-17A Interweaves the Skeletal and Immune Systems.Frontiers in immunology · 2020Review
- Construction of CII-Specific CAR-T to Explore the Cytokine Cascades Between Cartilage-Reactive T Cells and Chondrocytes.Frontiers in immunology · 2020Article
- CD226: An Emerging Role in Immunologic Diseases.Frontiers in cell and developmental biology · 2020Article
- Sonic Hedgehog Regulates Proliferation, Migration and Invasion of Synoviocytes in Rheumatoid ArthritisFrontiers in immunology · 2020Article
- The Emerging Roles of NDR1/2 in Infection and Inflammation.Frontiers in immunology · 2020Review
- Association of Interleukin-17F 7488A/G and 7383A/G Polymorphisms With Rheumatoid Arthritis: A Meta-Analysis.Archives of rheumatology · 2019Article
- A protocol for isolation and culture of mesenchymal stem cells from human gingival tissue.American journal of clinical and experimental immunology · 2019Article
- A protocol for humanized synovitis mice model.American journal of clinical and experimental immunology · 2019Article
- Human gingiva tissue-derived MSC ameliorates immune-mediated bone marrow failure of aplastic anemiaAmerican journal of translational research · 2019Article
- Interleukin-17A Plays the Same Role on Mice Acute Lung Injury Respectively Induced by Lipopolysaccharide and Paraquat.Inflammation · 2017Article
- Role of LncRNA-AF085935, IL-10 and IL-17 in Rheumatoid Arthritis Patients With Chronic Hepatitis C.Journal of clinical medicine research · 2017Article
- NDR1 protein kinase promotes IL-17- and TNF-α-mediated inflammation by competitively binding TRAF3.EMBO reports · 2017Article
- Article
- (5R)-5-hydroxytriptolide (LLDT-8) prevents collagen-induced arthritis through OPG/RANK/RANKL signaling in a rat model of rheumatoid arthritis.Experimental and therapeutic medicine · 2016Article
- IL17A and IL17F gene polymorphisms in patients with rheumatoid arthritis.BMC musculoskeletal disorders · 2016Article
Corrections and comments
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Authors and funding
10 authors at 1 institution in 1 country.
Funding
Abstract
Rheumatoid arthritis (RA) is a common autoimmune disease of chronic systemic inflammatory disorder that will affect multiple tissues and organs such as skin, heart or lungs; but it principally attacks the joints, producing a nonsuppurative inflammatory and proliferative synovitis that often progresses to major damaging of articular cartilage and joint ankylosis. Although the definite etiology is still unknown, recent studies suggest that T-helper cells (Th17) may play a pivotal role in the pathogenesis of RA. And interleukin-17 (IL-17), which is a cytokine of Th17 cells, may be a key factor in the occurrence of RA. The binding of IL-17 to specific receptor results in the expression of fibroblasts, endothelial and epithelial cells and also synthesis of several major factors such as tumor necrosis factor alpha (TNF-α), IL-1β that result in the structural damage of RA joints. Though some previous studies have shown that IL-17 exists in the synovium of RA, few has definite proof quantitatively by pathology about its existence in synovial membrane. This study comprised of 30 RA patients and 10 healthy control, pathologic study of the synovial membrane showed increased expression of IL-17 in the synovial tissue of RA patients, the intensity is compatible with clinical severity of disease as validated by DAS28 score and disease duration. Northern blot study also confirmed the increased expression of IL-17 in the synovial tissues. This study sheds further light that IL-17 may be a key factor in the pathogenesis of RA and a determinant of disease severity.
Indexed as
Identifiers
23826419PMC3693203W1526008582What OpenQuestion holds
Registered trials
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