ArticleInternational journal of clinical and experimental pathology2013
Hyperbaric oxygen therapy provides neuroprotection following spinal cord injury in a rat model.
Article in International journal of clinical and experimental pathology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 23 citations in OpenAlex.
- Application of hyperbaric oxygen therapy in the treatment of spinal cord injury: insights from preclinical to clinical evidence.Medical gas research · 2026Review
- Hyperbaric Oxygen Therapy in Traumatic and Non-Traumatic Spinal Cord Injuries: Insights from Nearly Five Decades of Evidence with Single-Center Experience.Brain sciences · 2026Article
- Hyperbaric Oxygen Therapy Attenuated the Motor Coordination and Cognitive Impairment of Polyglutamine Spinocerebellar Ataxia SCA17 Mice.Cerebellum (London, England) · 2024Article
- Oxygen therapy attenuates neuroinflammation after spinal cord injury.Journal of neuroinflammation · 2023Article
- Synergistic neuroprotective effects of hyperbaric oxygen and methylprednisolone following contusive spinal cord injury in rat.The journal of spinal cord medicine · 2022Article
- Hyperbaric Oxygen Therapy after Mid-Cervical Spinal Contusion Injury.Journal of neurotrauma · 2022Article
- Article
- Anti-inflammatory and anti-apoptotic effects of hyperbaric oxygen preconditioning in a rat model of cisplatin-induced peripheral neuropathy.Iranian journal of basic medical sciences · 2020Article
- Neuroprotective effects of hyperbaric oxygen (HBO) therapy on neuronal death induced by sciatic nerve transection in rat.BMC neurology · 2017Article
- Macrophage polarization: a key event in the secondary phase of acute spinal cord injury.Journal of cellular and molecular medicine · 2017Review
- Hyperbaric oxygen therapy combined with Schwann cell transplantation promotes spinal cord injury recovery.Neural regeneration research · 2015Article
- Hyperbaric oxygen therapy in China.Medical gas research · 2015Article
- Ligustilide treatment promotes functional recovery in a rat model of spinal cord injury via preventing ROS production.International journal of clinical and experimental pathology · 2015Article
- Hyperbaric oxygen treatment ameliorates lung injury in paraquat intoxicated rats.International journal of clinical and experimental pathology · 2015Article
- A review on the neuroprotective effects of hyperbaric oxygen therapy.Medical gas researchReview
Corrections and comments
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Authors and funding
10 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveTo investigate the effect of hyperbaric oxygen therapy (HBOT) on the iNOS mRNA-iNOS-NO signaling pathway and neurofunction protected in a rat spinal cord injury model.
methodsA total of 36 Sprague-Dawley rats were randomly divided into 3 groups: control group (n=12), SCI group (n=12) and SCI + HBOT group (n=12). SCI + HBOT group In the SCI group and SCI + HBOT groups, SCI was performed on rats. In the SCI + HBOT group, rats with SCI underwent HBO treatment 30 min after SCI for 24 sessions. After HBO therapy, measurement of motor evoked potential (MEP), Basso, Beattie, Bresnahan (BBB) scoring and pathological examination were done. RT-PCR and immunohistochemistry were employed to detect the mRNA and protein expression of iNOS, respectively. Diazo colorimetry was performed to detect the serum NO content.
resultsThe mRNA and protein expression of iNOS in the spinal cord and the serum NO content were markedly increased in the SCI group as compared to the control group (P<0.05). However, the mRNA and protein expression of iNOS and the serum NO content were dramatically reduced in the SCI + HBOT group as compared to the SCI group (P<0.05).
conclusionHBO therapy can promote the neuroprotection following SCI, which may be related to the effect of HBO on the iNOS mRNA-iNOS-NO signaling pathway.
Indexed as
Identifiers
23826414PMC3693198W1588781412What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.