ArticlePloS one2013
Identification and characterization of an antennae-specific aldehyde oxidase from the navel orangeworm.
Article in PloS one, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed.
- Article
- Structure of an antennally-expressed carboxylesterase suggests lepidopteran odorant degrading enzymes are broadly tuned.Current research in insect science · 2023Article
- Antennal transcriptomic analysis of carboxylesterases and glutathione S-transferases associated with odorant degradation in the tea gray geometrid,Frontiers in physiology · 2023Article
- Article
- Transcriptomic Identification and Expression Profile Analysis of Odorant-Degrading Enzymes from the Asian Corn Borer Moth,Insects · 2022Article
- Exploring the Terminal Pathway of Sex Pheromone Biosynthesis and Metabolism in the Silkworm.Insects · 2021Article
- An Overview of Antennal Esterases in Lepidoptera.Frontiers in physiology · 2021Review
- Article
- Identification and Characterization of Aldehyde Oxidase 5 in the Pheromone Gland of the Silkworm (Lepidoptera: Bombycidae).Journal of insect science (Online) · 2020Article
- Article
- Gypsy moth genome provides insights into flight capability and virus-host interactions.Proceedings of the National Academy of Sciences of the United States of America · 2019Article
- Identification and characterization of aldehyde oxidases (AOXs) in the cotton bollworm.Die Naturwissenschaften · 2017Article
- Neofunctionalization of "Juvenile Hormone Esterase Duplication" in Drosophila as an odorant-degrading enzyme towards food odorants.Scientific reports · 2017Article
- Article
- Morphological and Transcriptomic Analysis of a Beetle Chemosensory System Reveals a Gnathal Olfactory Center.BMC biology · 2016Article
- Article
- Transcriptome comparison of the sex pheromone glands from two sibling Helicoverpa species with opposite sex pheromone components.Scientific reports · 2015Article
- Antennal Transcriptome Analysis of Odorant Reception Genes in the Red Turpentine Beetle (RTB), Dendroctonus valens.PloS one · 2015Article
- Peripheral olfactory signaling in insects.Current opinion in insect science · 2014Article
- Putative pathway of sex pheromone biosynthesis and degradation by expression patterns of genes identified from female pheromone gland and adult antenna of Sesamia inferens (Walker).Journal of chemical ecology · 2014Article
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4 authors.
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No grant is acknowledged in the PubMed record.
Abstract
Antennae-specific odorant-degrading enzymes (ODEs) are postulated to inactivate odorant molecules after they convey their signal. Different classes of insect ODEs are specific to esters, alcohols, and aldehydes--the major functional groups of female-produced, hydrophobic sex pheromones from moth species. Esterases that rapidly inactive acetate and other esters have been well-studied, but less is known about aldehyde oxidases (AOXs). Here we report cloning of an aldehyde oxidase, AtraAOX2, from the antennae of the navel orangeworm (NOW), Amyelois transitella, and the first activity characterization of a recombinant insect AOX. AtraAOX2 gene spans 3,813 bp and encodes a protein with 1,270 amino acid residues. AtraAOX2 cDNA was expressed in baculovirus-infected insect Sf21 cells as a ≈280 kDa homodimer with 140 kDa subunits. Recombinant AtraAOX2 degraded Z11Z13-16Ald and plant volatile aldehydes as substrates. However, as expected for aldehyde oxidases, recombinant AtraAOX2 did not show specificity for Z11Z13-16Ald, the main constituent of the sex pheromone, but showed high activity for plant volatile aldehydes. Our data suggest AtraAOX2 might be involved in degradation of a diversity of aldehydes including sex pheromones, plant-derived semiochemicals, and chemical cues for oviposition sites. Additionally, AtraAOX2 could protect the insect's olfactory system from xenobiotics, including pesticides that might reach the sensillar lymph surrounding the olfactory receptor neurons.
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