ArticlePloS one2013
Retinal Thickness Normative Data in Wild-Type Mice Using Customized Miniature SD-OCT.
Article in PloS one, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 56 papers.
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Who cites it
56 citing papers in PubMed, 85 citations in OpenAlex.
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- Characterization of the ocular inflammatory response to AAV reveals divergence by sex and age.Molecular therapy : the journal of the American Society of Gene Therapy · 2025Article
- Insights into Myopia from Mouse Models.Annual review of vision science · 2024Review
- Age-Related Retinal Layer Thickness Changes Measured by OCT inInternational journal of molecular sciences · 2024Article
- miR-92b-3p protects retinal tissues against DNA damage and apoptosis by targeting BTG2 in experimental myopia.Journal of translational medicine · 2024Article
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- Complement propagates visual system pathology following traumatic brain injury.Journal of neuroinflammation · 2024Article
- OCT Imaging in Murine Models of Alzheimer's Disease in a Systematic Review: Findings, Methodology and Future Perspectives.Biomedicines · 2024Review
- An osmolarity dependent mechanism partially ameliorates retinal cysts and rescues cone function in a mouse model of X-linked retinoschisis.Frontiers in medicine · 2024Article
- Dipeptide alanine-glutamine ameliorates retinal neurodegeneration in an STZ-induced rat model.Frontiers in pharmacology · 2024Article
- Evaluating the performance of OCT in assessing static and potential dynamic properties of the retinal ganglion cells and nerve fiber bundles in the living mouse eye.Biomedical optics express · 2023Article
- Sufficient Cav-1 levels in the endothelium are critical for the maintenance of the neurovascular unit in the retina.Molecular medicine (Cambridge, Mass.) · 2023Article
- Human equivalent doses of L-DOPA rescues retinal morphology and visual function in a murine model of albinism.Scientific reports · 2023Article
- Functional and structural changes in the neuroretina are accompanied by mitochondrial dysfunction in a type 2 diabetic mouse model.Eye and vision (London, England) · 2023Article
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveTo report normative data for retinal thickness in wild-type C57BL/6 mouse utilizing a miniature SD-OCT system.
methodsTHIRTY ADULT MICE (RANGE: 3-5 months) were anesthetized and secured into the Bioptigen Spectral Domain Ophthalmic Imaging System. Right eye SD-OCT images were standardized by centralizing the optic nerve head (ONH) prior to image acquisition. Global and quadrant total retinal thickness (TRT) values were measured from retinal nerve fiber layer to retinal pigment epithelial layer. Posterior segment analyses also included the outer retinal layer (ORL) and inner retinal layer (IRL). Further sublayer analyses of four layers from the ORL and three layers comprising the IRL were also performed.
resultsThe overall mean±SD global TRT in a C57BL/6 mouse model was 204.41±5.19 µm. Quadrant mean TRT values were 204.85±5.81 µm inferiorly, 204.97±6.71 µm nasally, 205.08±5.44 µm temporally, and 202.74±4.85 µm superiorly. Mean±SD thickness for ORL, and IRL were 126.37±10.01 µm, and 107.03±10.98 µm respectively. The mean±SD estimates for the four layers of the ORL were 18.23±2.73 µm, 26.04±4.21 µm, 63.8±6.23 µm, and 19.22±4.34 µm. Mean±SD values for the three IRL sublayers were 27.82±4.04 µm, 59.62±6.66 µm and 19.12±3.71 µm.
conclusionThis study established normative values for the total retinal thickness and sublayer thickness for the wild-type C57BL/6 mice. Moreover, it provides a standard of retinal morphology, in a commonly used animal model, for evaluating therapeutic interventions and retinal disease pathophysiology.
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