ArticlePloS one2013
Reversible femtosecond laser-assisted myopia correction: a non-human primate study of lenticule re-implantation after refractive lenticule extraction.
Article in PloS one, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers, 2 of them syntheses that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
25 citing papers in PubMed, 2 syntheses or guidelines pooled it, 89 citations in OpenAlex.
- Femtosecond laser-assisted stromal keratophakia for keratoconus: A systemic review and meta-analysis.International ophthalmology · 2021Pooled it
- Femtosecond laser-assisted implantation of corneal stroma lenticule for keratoconus.International ophthalmology · 2021Pooled it
- Preservation and Reuse of KLEx Lenticules: From Biobanking to Therapeutic and Refractive Innovations.Bioengineering (Basel, Switzerland) · 2026Review
- [New tissue-additive procedures to improve vision in keratoconus].Die Ophthalmologie · 2026Review
- Ex vivo evaluation of corneal filler injection for enhancement after small incision lenticule extraction.Scientific reports · 2025Article
- Banking of post-SMILE stromal lenticules for additive keratoplasty: A new challenge for eye banks?International ophthalmology · 2024Review
- Ex Vivo Lenticule Customization for Stromal Lenticule Addition Keratoplasty.Investigative ophthalmology & visual science · 2024Article
- Applications of SMILE-extracted lenticules in ophthalmology.International journal of ophthalmology · 2024Review
- The new future perspective in corneal tissue utilisation - methods of preparation and preservation.BMC ophthalmology · 2023Article
- Incisional surface quality of electron-beam irradiated cornea-extracted lenticule for stromal keratophakia: high nJ-energy vs. low nJ-energy femtosecond laser.Frontiers in medicine · 2023Article
- Update of Research Progress on Small Incision Lenticule Extraction (SMILE) Lenticule Reuse.Clinical ophthalmology (Auckland, N.Z.) · 2023Review
- Preservation of corneal stromal lenticule: review.Cell and tissue banking · 2022Review
- Effect of corneal stromal lenticule customization on neurite distribution and excitatory property.Journal of advanced research · 2022Article
- Femtosecond Laser-Assisted Small Incision Allogeneic Endokeratophakia Using a Hyperopic Lenticule in Rabbits.Translational vision science & technology · 2021Article
- Epithelial and stromal remodelling following femtosecond laser-assisted stromal lenticule addition keratoplasty (SLAK) for keratoconus.Scientific reports · 2021Article
- Corneal Stromal Regeneration: A Review of Human Clinical Studies in Keratoconus Treatment.Frontiers in medicine · 2021Review
- Small-incision lenticule addition in ex vivo model of ectatic human corneas.International ophthalmology · 2019Article
- Two-year outcome of an eye that underwent hyperopic LASIK following inadvertent myopic SMILE lenticule in situ implantation.BMC ophthalmology · 2019Article
- Corneal remodelling and topography following biological inlay implantation with combined crosslinking in a rabbit model.Scientific reports · 2019Article
- Hyperopic refractive correction by LASIK, SMILE or lenticule reimplantation in a non-human primate model.PloS one · 2018Article
Corrections and comments
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Authors and funding
6 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
LASIK (laser-assisted in situ keratomileusis) is a common laser refractive procedure for myopia and astigmatism, involving permanent removal of anterior corneal stromal tissue by excimer ablation beneath a hinged flap. Correction of refractive error is achieved by the resulting change in the curvature of the cornea and is limited by central corneal thickness, as a thin residual stromal bed may result in biomechanical instability of the cornea. A recently developed alternative to LASIK called Refractive Lenticule Extraction (ReLEx) utilizes solely a femtosecond laser (FSL) to incise an intrastromal refractive lenticule (RL), which results in reshaping the corneal curvature and correcting the myopia and/or astigmatism. As the RL is extracted intact in the ReLEx, we hypothesized that it could be cryopreserved and re-implanted at a later date to restore corneal stromal volume, in the event of keratectasia, making ReLEx a potentially reversible procedure, unlike LASIK. In this study, we re-implanted cryopreserved RLs in a non-human primate model of ReLEx. Mild intrastromal haze, noted during the first 2 weeks after re-implantation, subsided after 8 weeks. Refractive parameters including corneal thickness, anterior curvature and refractive error indices were restored to near pre-operative values after the re-implantation. Immunohistochemistry revealed no myofibroblast formation or abnormal collagen type I expression after 8 weeks, and a significant attenuation of fibronectin and tenascin expression from week 8 to 16 after re-implantation. In addition, keratocyte re-population could be found along the implanted RL interfaces. Our findings suggest that RL cryopreservation and re-implantation after ReLEx appears feasible, suggesting the possibility of potential reversibility of the procedure, and possible future uses of RLs in treating other corneal disorders and refractive errors.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.