ArticlePloS one2013
The MAT locus genes play different roles in sexual reproduction and pathogenesis in Fusarium graminearum.
Article in PloS one, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 49 papers.
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Who cites it
49 citing papers in PubMed.
- Structural Diversity and Differential Natural Pairings of MAT1-1-1 and MAT1-2-1 Proteins Essential for Sexual Reproduction inInternational journal of molecular sciences · 2026Article
- Homothallic or Heterothallic? A Genomic Investigation Into the Sexual Capabilities of the Ascomycete Fungus Clonostachys rosea.Molecular ecology · 2026Article
- FgJhd2 Modulates FgMpf2 Expression via H3K4 Demethylation and Influences Sexual Development in Fusarium graminearum.Environmental microbiology · 2026Article
- Mating-Type Loci Modulate Pathogenicity and Non-Sexual Development Through Autocrine Pheromone Signalling in the Asexual Fungus Fusarium oxysporum.Molecular plant pathology · 2026Article
- Article
- Gip1 GPCR regulates two sexual-stage differentiation processes in the ascomycete Fusarium graminearum.Nature communications · 2025Article
- Article
- Transgressive phenotypes from outbreeding between theMicrobiology spectrum · 2024Article
- An Antisense Long Non-Coding RNA, LncRsn, Is Involved in Sexual Reproduction and Full Virulence inJournal of fungi (Basel, Switzerland) · 2024Article
- A winged-helix DNA-binding protein is essential for self-fertility during sexual development of the homothallic fungusmSphere · 2024Article
- Unveiling the A-to-I mRNA editing machinery and its regulation and evolution in fungi.Nature communications · 2024Article
- Article
- Advances in UnderstandingGenes · 2024Review
- Draft genome sequence data ofData in brief · 2024Article
- Structure of the Mating-Type Genes and Mating Systems ofJournal of fungi (Basel, Switzerland) · 2023Article
- Ploidy evolution in a wild yeast is linked to an interaction between cell type and metabolism.PLoS biology · 2023Article
- A non-pheromone GPCR is essential for meiosis and ascosporogenesis in the wheat scab fungus.Proceedings of the National Academy of Sciences of the United States of America · 2023Article
- The Mating Type (MAT) and Virulence ofMicroorganisms · 2023Article
- Needles in fungal haystacks: Discovery of a putative a-factor pheromone and a unique mating strategy in the Leotiomycetes.PloS one · 2023Article
- The Role of Chromatin and Transcriptional Control in the Formation of Sexual Fruiting Bodies in Fungi.Microbiology and molecular biology reviews : MMBR · 2022Review
Corrections and comments
- Erratum issued
Authors and funding
9 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Sexual reproduction plays a critical role in the infection cycle of Fusarium graminearum because ascospores are the primary inoculum. As a homothallic ascomycete, F. graminearum contains both the MAT1-1 and MAT1-2-1 loci in the genome. To better understand their functions and regulations in sexual reproduction and pathogenesis, in this study we assayed the expression, interactions, and mutant phenotypes of individual MAT locus genes. Whereas the expression of MAT1-1-1 and MAT12-1 rapidly increased after perithecial induction and began to decline after 1 day post-perithecial induction (dpi), the expression of MAT1-1-2 and MAT1-1-3 peaked at 4 dpi. MAT1-1-2 and MAT1-1-3 had a similar expression profile and likely are controlled by a bidirectional promoter. Although none of the MAT locus genes were essential for perithecium formation, all of them were required for ascosporogenesis in self-crosses. In outcrosses, the mat11-1-2 and mat11-1-3 mutants were fertile but the mat1-1-1 and mat1-2-1 mutants displayed male- and female-specific defects, respectively. The mat1-2-1 mutant was reduced in FgSO expression and hyphal fusion. Mat1-1-2 interacted with all other MAT locus transcription factors, suggesting that they may form a protein complex during sexual reproduction. Mat1-1-1 also interacted with FgMcm1, which may play a role in controlling cell identity and sexual development. Interestingly, the mat1-1-1 and mat1-2-1 mutants were reduced in virulence in corn stalk rot assays although none of the MAT locus genes was important for wheat infection. The MAT1-1-1 and MAT1-2-1 genes may play a host-specific role in colonization of corn stalks.
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