ArticlePloS one2013
Molecular fingerprint of high fat diet induced urinary bladder metabolic dysfunction in a rat model.
Article in PloS one, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 20 citations in OpenAlex.
- High-fat diet feeding reduced smooth muscle contractility and increasing tissue programmed death activity in rats bladder tissue.International urology and nephrology · 2026Article
- Review
- Potential role for vitamin D vs. intermittent fasting in controlling aquaporin-1 and aquaporin-3 expression in HFD-induced urinary bladder alterations in rats.Frontiers in molecular biosciences · 2023Article
- Tadalafil ameliorates bladder overactivity by restoring insulin-activated detrusor relaxation via the bladder mucosal IRS/PI3K/AKT/eNOS pathway in fructose-fed rats.Scientific reports · 2021Article
- Physical activity effects on bladder dysfunction in an obese and insulin-resistant murine model.Physiological reports · 2021Article
- Urinary metabolomics predict the severity of overactive bladder syndrome in an aging female population.International urogynecology journal · 2020Article
- Gastric mucosal devitalization improves blood pressure, renin and cardiovascular lipid deposition in a rat model of obesity.Endoscopy international open · 2019Article
- Chronic high-fat diet decreased detrusor mitochondrial respiration and increased nerve-mediated contractions.Neurourology and urodynamics · 2019Article
- Obesity-initiated metabolic syndrome promotes urinary voiding dysfunction in a mouse model.The Prostate · 2016Article
- The future of research in female pelvic medicine.Current urology reports · 2015Article
- [High fat diet-induced molecular and physiological dysfunction of the urinary bladder].Der Urologe. Ausg. A · 2014Article
- Weight loss surgery improves the metabolic status in an obese rat model but does not affect bladder fibrosis associated with high fat diet feeding.International journal of obesity (2005) · 2014Article
- Effect of a high-fat diet on the rat bladder wall and bioactive action of Brazil nut oil.International braz j urol : official journal of the Brazilian Society of UrologyArticle
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Authors and funding
11 authors at 5 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
aims/hypothesisDiabetic voiding dysfunction has been reported in epidemiological dimension of individuals with diabetes mellitus. Animal models might provide new insights into the molecular mechanisms of this dysfunction to facilitate early diagnosis and to identify new drug targets for therapeutic interventions.
methodsThirty male Sprague-Dawley rats received either chow or high-fat diet for eleven weeks. Proteomic alterations were comparatively monitored in both groups to discover a molecular fingerprinting of the urinary bladder remodelling/dysfunction. Results were validated by ELISA, Western blotting and immunohistology.
resultsIn the proteome analysis 383 proteins were identified and canonical pathway analysis revealed a significant up-regulation of acute phase reaction, hypoxia, glycolysis, β-oxidation, and proteins related to mitochondrial dysfunction in high-fat diet rats. In contrast, calcium signalling, cytoskeletal proteins, calpain, 14-3-3η and eNOS signalling were down-regulated in this group. Interestingly, we found increased ubiquitin proteasome activity in the high-fat diet group that might explain the significant down-regulation of eNOS, 14-3-3η and calpain. CONCLUSIONS/
interpretationThus, high-fat diet is sufficient to induce significant remodelling of the urinary bladder and alterations of the molecular fingerprint. Our findings give new insights into obesity related bladder dysfunction and identified proteins that may indicate novel pathophysiological mechanisms and therefore constitute new drug targets.
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