Trial reportPloS one2013
Prenatal vitamin d supplementation and child respiratory health: a randomised controlled trial.
Trial report in PloS one, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 81 papers, 18 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
81 citing papers in PubMed, 18 syntheses or guidelines pooled it, 177 citations in OpenAlex.
- Effects of Maternal Vitamin D Supplementation on Childhood Health.Endocrine reviews · 2026Pooled it
- Effects of Maternal Vitamin D Supplementation on Childhood Health.Endocrine reviews · 2025Pooled it
- Association between prenatal vitamin D supplementation and respiratory diseases in children: a systematic review and meta-analysis.BMC pediatrics · 2025Pooled it
- Vitamin D supplementation in pregnant or breastfeeding women or young children for preventing asthma.The Cochrane database of systematic reviews · 2025Pooled it
- Vitamin D Supplementation and Allergic Rhinitis: A Systematic Review and Meta-Analysis.Medicina (Kaunas, Lithuania) · 2025Pooled it
- Vitamin D supplementation for women during pregnancy.The Cochrane database of systematic reviews · 2024Pooled it
- Vitamin D Supplementation and Vitamin D Status during Pregnancy and the Risk of Congenital Anomalies-A Systematic Review and Meta-Analysis.Nutrients · 2023Pooled it
- Vitamin D for the management of asthma.The Cochrane database of systematic reviews · 2023Pooled it
- The maternal diet index in pregnancy is associated with offspring allergic diseases: the Healthy Start study.Allergy · 2022Pooled it
- Pooled it
- Dietary factors during pregnancy and atopic outcomes in childhood: A systematic review from the European Academy of Allergy and Clinical Immunology.Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology · 2020Pooled it
- Vitamin D supplementation for women during pregnancy.The Cochrane database of systematic reviews · 2019Pooled it
- Effects of Vitamin D Supplementation During Pregnancy on Birth Size: A Systematic Review and Meta-Analysis of Randomized Controlled Trials.Nutrients · 2019Pooled it
- Early life vitamin D status and asthma and wheeze: a systematic review and meta-analysis.BMC pulmonary medicine · 2018Pooled it
- Association Between Vitamin D Supplementation During Pregnancy and Offspring Growth, Morbidity, and Mortality: A Systematic Review and Meta-analysis.JAMA pediatrics · 2018Pooled it
- Pooled it
- Maternal and cord blood vitamin D status and childhood infection and allergic disease: a systematic review.Nutrition reviews · 2016Pooled it
- Vitamin D supplementation higher than 2000 IU/day compared to lower dose on maternal-fetal outcome: Systematic review and meta-analysis.Women's health (London, England)Pooled it
- The Impact of Baseline 25-Hydroxyvitamin D Level and Gestational Age on Prenatal Vitamin D Supplementation to Prevent Offspring Asthma or Recurrent Wheezing.The American journal of clinical nutrition · 2023Trial
- Trial
21 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
12 authors at 4 institutions in 1 country.
Funding
Abstract
backgroundObservational studies suggest high prenatal vitamin D intake may be associated with reduced childhood wheezing. We examined the effect of prenatal vitamin D on childhood wheezing in an interventional study.
methodsWe randomised 180 pregnant women at 27 weeks gestation to either no vitamin D, 800 IU ergocalciferol daily until delivery or single oral bolus of 200,000 IU cholecalciferol, in an ethnically stratified, randomised controlled trial. Supplementation improved but did not optimise vitamin D status. Researchers blind to allocation assessed offspring at 3 years. Primary outcome was any history of wheeze assessed by validated questionnaire. Secondary outcomes included atopy, respiratory infection, impulse oscillometry and exhaled nitric oxide. Primary analyses used logistic and linear regression.
resultsWe evaluated 158 of 180 (88%) offspring at age 3 years for the primary outcome. Atopy was assessed by skin test for 95 children (53%), serum IgE for 86 (48%), exhaled nitric oxide for 62 (34%) and impulse oscillometry of acceptable quality for 51 (28%). We found no difference between supplemented and control groups in risk of wheeze [no vitamin D: 14/50 (28%); any vitamin D: 26/108 (24%) (risk ratio 0.86; 95% confidence interval 0.49, 1.50; P = 0.69)]. There was no significant difference in atopy, eczema risk, lung function or exhaled nitric oxide between supplemented groups and controls.
conclusionPrenatal vitamin D supplementation in late pregnancy that had a modest effect on cord blood vitamin D level, was not associated with decreased wheezing in offspring at age three years.
trial registrationControlled-Trials.com ISRCTN68645785.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.