ArticleJournal of research in medical sciences : the official journal of Isfahan University of Medical Sciences2012
Is prehypertension a risk factors for cardiovascular diseases among Iranian women?
Article in Journal of research in medical sciences : the official journal of Isfahan University of Medical Sciences, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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2 citing papers in PubMed, 10 citations in OpenAlex.
- Hypertension and mortality in the Golestan Cohort Study: A prospective study of 50 000 adults in Iran.Journal of human hypertension · 2016Article
- Translation and validation of the Persian version of the treatment adherence questionnaire for patients with hypertension.ARYA atherosclerosis · 2016Article
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Authors and funding
5 authors at 1 institution in 1 country.
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Abstract
backgroundNumerous studies have reported prehypertension (pre-HTN) as a risk factor for the cardiovascular diseases as hypertension (HTN).
aimThe present study aimed to evaluate the effects of pre-HTN on cardiovascular incidences among the females of Isfahan cohort study (ICS). MATERIALS AND
methodsHealthy female at baseline were followed for a median of 6.7 years. They were divided into 3 groups of normal blood pressure, pre-HTN (120/80 < BP < 139/89 mmHg) and HTN (BP > 140/90 mmHg) based on their baseline measurements. The endpoints were ischemic heart disease (IHD), stroke, CVD (combination of IHD and stroke) and mortality.
resultsNormal BP, pre-HTN and HTN were observed in 1073 (33%), 1185 (36%), and 994 (31%) participants, respectively. One hundred and ninety-eight subjects developed CVDs and 110 died. In the HTN group, the hazard ratio [HRs (95% confidence interval)] adjusted for age and other risk factors were 3.44 (1.95-6.09) for IHD (P value < 0.001), 1.28 (0.59-2.77) for stroke (P value = 0.536) 4.89 (1.37-17.45) for CVD mortality (P value < 0.001) and 1.70 (0.98-2.96) for all cause mortality (P value = 0.060). Although, pre-HTN significantly increased the risk of IHD incidence in the crude model (HR 2.21, 95% CI 1.23-3.97) and after adjustments for age (HR 1.85, 95% CI 1.02-3.33), (P value < 0.001) the association did not remain statistically significant after including other risk factors in the model.
conclusionHypertension (HTN) to be a strong risk factor for CVD and IHD. However, in contrast to previous researches, pre-HTN was not found to be a risk factor for CVD, IHD or death independent to other risk factors in women.
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23825995PMC3698654W1778383629What OpenQuestion holds
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