ArticlePLoS genetics2013
Environmental dependence of genetic constraint.
Article in PLoS genetics, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers.
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Who cites it
33 citing papers in PubMed.
- Environment-dependent epistasis shapes adaptation to fluctuating resources.bioRxiv : the preprint server for biology · 2026Article
- Genomic Offsets Predict Survival With Low Accuracy in a Marine Common Garden.Molecular ecology · 2026Article
- Microbial interactions in facilitating antibiotic activity and resistance evolution.Applied and environmental microbiology · 2026Review
- Article
- The highly rugged yet navigable regulatory landscape of the bacterial transcription factor TetR.Nature communications · 2024Article
- Multi-Attribute Subset Selection enables prediction of representative phenotypes across microbial populations.Communications biology · 2024Article
- Evolutionary "Crowdsourcing": Alignment of Fitness Landscapes Allows for Cross-species Adaptation of a Horizontally Transferred Gene.Molecular biology and evolution · 2023Article
- Environment-dependent epistasis increases phenotypic diversity in gene regulatory networks.Science advances · 2023Article
- Rheostat functional outcomes occur when substitutions are introduced at nonconserved positions that diverge with speciation.Protein science : a publication of the Protein Society · 2021Article
- The adaptive landscape of a metallo-enzyme is shaped by environment-dependent epistasis.Nature communications · 2021Article
- Dynamic genetic architecture of yeast response to environmental perturbation shed light on origin of cryptic genetic variation.PLoS genetics · 2020Article
- Recombining Your Way Out of Trouble: The Genetic Architecture of Hybrid Fitness under Environmental Stress.Molecular biology and evolution · 2020Article
- Diversity inmBio · 2019Article
- Recent insights into the genotype-phenotype relationship from massively parallel genetic assays.Evolutionary applications · 2019Review
- Synthetic circuits reveal how mechanisms of gene regulatory networks constrain evolution.Molecular systems biology · 2018Article
- Experimental Studies of Evolutionary Dynamics in Microbes.Trends in genetics : TIG · 2018Review
- Selecting among three basic fitness landscape models: Additive, multiplicative and stickbreaking.Theoretical population biology · 2018Article
- Multi-environment fitness landscapes of a tRNA gene.Nature ecology & evolution · 2018Article
- Local Fitness Landscapes Predict Yeast Evolutionary Dynamics in Directionally Changing Environments.Genetics · 2018Article
- Article
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Authors and funding
5 authors.
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Abstract
The epistatic interactions that underlie evolutionary constraint have mainly been studied for constant external conditions. However, environmental changes may modulate epistasis and hence affect genetic constraints. Here we investigate genetic constraints in the adaptive evolution of a novel regulatory function in variable environments, using the lac repressor, LacI, as a model system. We have systematically reconstructed mutational trajectories from wild type LacI to three different variants that each exhibit an inverse response to the inducing ligand IPTG, and analyzed the higher-order interactions between genetic and environmental changes. We find epistasis to depend strongly on the environment. As a result, mutational steps essential to inversion but inaccessible by positive selection in one environment, become accessible in another. We present a graphical method to analyze the observed complex higher-order interactions between multiple mutations and environmental change, and show how the interactions can be explained by a combination of mutational effects on allostery and thermodynamic stability. This dependency of genetic constraint on the environment should fundamentally affect evolutionary dynamics and affects the interpretation of phylogenetic data.
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Registered trials
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