ArticleChinese journal of cancer research = Chung-kuo yen cheng yen chiu2013
Matrix metalloproteinase gene expressions might be oxidative stress targets in gastric cancer cell lines.
Article in Chinese journal of cancer research = Chung-kuo yen cheng yen chiu, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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19 citing papers in PubMed, 33 citations in OpenAlex.
- MMP12 deficiency attenuates menthol e-cigarette plus house dust-mite effects on pulmonary iron homeostasis and oxidative stress.Respiratory research · 2025Article
- Effects of pyrrolopyrimidine derivatives on cancer cells cultured in vitro and potential mechanism.Naunyn-Schmiedeberg's archives of pharmacology · 2024Article
- The substance P/ neurokinin-1 receptor signaling pathway mediates metastasis in human colorectal SW480 cancer cells.Molecular biology reports · 2022Article
- Deficiency in Lyst function leads to accumulation of secreted proteases and reduced retinal adhesion.PloS one · 2022Article
- Retinal Physiology and Circulation: Effect of Diabetes.Comprehensive Physiology · 2020Review
- Association of matrix metalloproteinases 3 and 9 single nucleotide polymorphisms with breast cancer risk: A case-control study.Molecular and clinical oncology · 2020Article
- Prognostic value of preoperative serum bilirubin levels in ovarian cancer.American journal of translational research · 2020Article
- Loss of Platelet Endothelial Cell Adhesion Molecule-1 (PECAM-1) in the Diabetic Retina: Role of Matrix Metalloproteinases.Investigative ophthalmology & visual science · 2019Article
- MT4-MMP: The GPI-Anchored Membrane-Type Matrix Metalloprotease with Multiple Functions in Diseases.International journal of molecular sciences · 2019Review
- Effect of Chitosan Nanoparticle-LoadedStem cells international · 2019Article
- Cisplatin-induced oxidative stress stimulates renal Fas ligand shedding.Renal failure · 2018Article
- The function of MMP-28/TGF-β induced cell apoptosis in human glioma cells.Experimental and therapeutic medicine · 2018Article
- Transcriptomics analysis reveals new insights in E171-induced molecular alterations in a mouse model of colon cancer.Scientific reports · 2018Article
- Nutritional and Pharmacological Effects on Oxidative Stress in Soft Tissue and Bone Remodeling.Journal of nutrition and metabolism · 2018Review
- Identifying key stage-specific genes and transcription factors for gastric cancer based on RNA-sequencing data.Medicine · 2017Article
- Metalloproteinases as mediators of inflammation and the eyes: molecular genetic underpinnings governing ocular pathophysiology.International journal of ophthalmology · 2017Review
- Increased phosphorylation of eIF2α in chronic myeloid leukemia cells stimulates secretion of matrix modifying enzymes.Oncotarget · 2016Article
- Schisandrin B inhibits the proliferation of human lung adenocarcinoma A549 cells by inducing cycle arrest and apoptosis.International journal of clinical and experimental medicine · 2015Article
- Prognostic value of matrix metalloprotease-1/protease-activated receptor-1 axis in patients with prostate cancer.Medical oncology (Northwood, London, England) · 2014Article
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3 authors at 1 institution in 1 country.
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No grant is acknowledged in the PubMed record.
Abstract
objectiveOxidative stress is linked to increased risk of gastric cancer and matrix metalloproteinases (MMPs) are important in the invasion and metastasis of gastric cancer. We aimed to analyze the effect of the accumulation of oxidative stress in the gastric cancer MKN-45 and 23132/87 cells following hydrogen peroxide (H2O2) exposure on the expression patterns of MMP-1, MMP-3, MMP-7, MMP-9, MMP-10, MMP-11, MMP-12, MMP-14, MMP-15, MMP-17, MMP-23, MMP-28, and β-catenin genes.
methodsThe mRNA transcripts in the cells were determined by RT-PCR. Following H2O2 exposure, oxidative stress in the viable cells was analyzed by 2',7'-dichlorofluorescein diacetate (DCFH-DA). Caffeic acid phenethyl ester (CAPE) was used to eliminate oxidative stress and the consequence of H2O2 exposure and its removal on the expressions of the genes were evaluated by quantitative real-time PCR.
resultsThe expressions of MMP-1, MMP-7, MMP-14, MMP-15, MMP-17 and β-catenin in MKN-45 cells and only the expression of MMP-15 in 23132/87 cells were increased. Removal of the oxidative stress resulted in decrease in the expressions of MMP genes of which the expressions were increased after H2O2 exposure. β-catenin, a transcription factor for many genes including MMPs, also displayed decreased levels of expression in both of the cell lines following CAPE treatment.
conclusionsOur data suggest that there is a remarkable link between the accumulation of oxidative stress and the increased expressions of MMP genes in the gastric cancer cells and MMPs should be considered as potential targets of therapy in gastric cancers due to its continuous exposure to oxidative stress.
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