ArticleIranian journal of microbiology2013
The occurrence of extended-spectrum β-lactamase producing Shigella spp. in Tehran, Iran.
Article in Iranian journal of microbiology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 26 citations in OpenAlex.
- Molecular characterization and antimicrobial resistance profiles of Shigella flexneri isolates from pediatric clinical cases in Ahvaz, Iran.Scientific reports · 2026Article
- Determination of ESBLs, pAmpC-beta-lactamase genes, and plasmid replicon types amongArchives of Razi Institute · 2025Article
- Study of Antimicrobial Resistance (AMR) inRecent advances in anti-infective drug discovery · 2024Review
- Using a combination of short- and long-read sequencing to investigate the diversity in plasmid- and chromosomally encoded extended-spectrum beta-lactamases (ESBLs) in clinicalMicrobial genomics · 2023Article
- Molecular detection and characterization of Shigella spp. harboring extended-spectrum β-lactamase genes in children with diarrhea in northwest Iran.Molecular and cellular pediatrics · 2022Article
- Diarrhea in an infant due to Shigella flexneri 1 carrying multiple cephalosporinase-encoding genes.Gut pathogens · 2021Article
- Extended spectrum beta-lactamase and fluoroquinolone resistance genes among Escherichia coli and Salmonella isolates from children with diarrhea, Burkina Faso.BMC pediatrics · 2020Article
- Article
- Phenotypic and Molecular Epidemiology of ESBL-, AmpC-, and Carbapenemase-ProducingFrontiers in microbiology · 2019Article
- Increasing clinical resistance rate ofAnnals of translational medicine · 2018Article
- The Frequency of Antibiotic Resistance and ESBLs Among ClinicallyThe open microbiology journal · 2018Article
- The Prevalence of CTX-M-15 Extended-spectrum β-Lactamases AmongEuropean journal of microbiology & immunology · 2017Article
- Genetic Investigation of Beta-Lactam Associated Antibiotic Resistance AmongThe open microbiology journal · 2017Article
- Surveillance of Bacterial Pathogens of Diarrhoea in Two Selected Sub Metros Within the Accra Metropolis.Ghana medical journal · 2015Article
- Diversity of Variable Number Tandem Repeat Loci in Shigella Species Isolated from Pediatric Patients.International journal of molecular and cellular medicine · 2015Article
- Development of Multiplex PCR for Simultaneous Detection of Three Pathogenic Shigella Species.Iranian journal of public health · 2014Article
- Molecular evaluations of extended spectrum β-lactamase producing strains of Serratia isolated from blood samples of the patients in Namazi Hospital, Shiraz, Southern Iran.Iranian journal of microbiology · 2013Article
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Authors and funding
9 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
BACKGROUND AND
objectivesThe emergence of extended-spectrum β-lactamase (ESBL)-producing Shigella spp. is of increasing clinical concern specially in children worldwide. The aim of this study was to investigate the occurrence of extended-spectrum β-lactamase producing Shigella spp. in Tehran, Iran. MATERIALS AND
methodsThe study included all Shigella isolates recovered from pediatric patients aged less than 12 years admitted to a major pediatric hospital in Tehran, Iran, from 2008 to 2010. Bacterial identification, antimicrobial susceptibility testing, extended spectrum β-lactamases (ESBLs) screening and confirmatory tests were performed according to the standard guidelines. Conjugal transfer experiments and plasmid analysis were also carried out. Polymerase chain reaction and sequencing were used to identify the genetic determinants responsible for ESBL production.
resultsFour out of 55 Shigella isolates, including three S. sonnei and one S. flexneri, showed an ESBL-positive phenotype. Plasmid transfer of the ESBL phenotype was successful for the S. flexneri isolate only. By PCR and sequencing, one S. sonnei isolate tested positive for the CMY-59 gene, while the other two S. sonnei and the S. flexneri isolates tested positive for the bla TEM-1 and bla CTX-M-15 genes.
conclusionWe found the prevalence of ESBL producing Shigella isolates was higher than detection rates observed in many other countries. Our finding raise concerns about the dissemination of ESBL among the strains of endemic S. sonnei throughout the country, because this species is now the most frequently isolated Shigella species in Iran and shigellosis by such strains in the community can pose a significant threat to patients and presents a challenge for disease management.
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Identifiers
23825726PMC3696844W1894820083What OpenQuestion holds
Registered trials
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