ArticlePloS one2013
Convergent Findings of Altered Functional and Structural Brain Connectivity in Individuals with High Functioning Autism: A Multimodal MRI Study.
Article in PloS one, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 80 papers, 7 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
80 citing papers in PubMed, 7 syntheses or guidelines pooled it, 153 citations in OpenAlex.
- Common and distinct cortical thickness alterations in youth with autism spectrum disorder and attention-deficit/hyperactivity disorder.BMC medicine · 2024Pooled it
- Atypical local brain connectivity in pediatric autism spectrum disorder? A coordinate-based meta-analysis of regional homogeneity studies.European archives of psychiatry and clinical neuroscience · 2024Pooled it
- A meta-analytic investigation of grey matter differences in anorexia nervosa and autism spectrum disorder.European eating disorders review : the journal of the Eating Disorders Association · 2022Pooled it
- Neural Effects of Physical Activity and Movement Interventions in Individuals With Developmental Disabilities-A Systematic Review.Frontiers in psychiatry · 2022Pooled it
- Comparative meta-analyses of brain structural and functional abnormalities during cognitive control in attention-deficit/hyperactivity disorder and autism spectrum disorder.Psychological medicine · 2020Pooled it
- Resting-state abnormalities in Autism Spectrum Disorders: A meta-analysis.Scientific reports · 2019Pooled it
- Disrupted focal white matter integrity in autism spectrum disorder: A voxel-based meta-analysis of diffusion tensor imaging studies.Progress in neuro-psychopharmacology & biological psychiatry · 2018Pooled it
- Effects of cannabidiol on brain excitation and inhibition systems; a randomised placebo-controlled single dose trial during magnetic resonance spectroscopy in adults with and without autism spectrum disorder.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2019Trial
- Increased sensitivity in identifying language-related functional connectivity using jackknife resampling analyses.Network neuroscience (Cambridge, Mass.) · 2026Article
- Age-stratified multimodal MRI and machine learning to explore autism-related brain characteristics in youth.Frontiers in psychiatry · 2026Article
- Exploring the Autistic Brain: A Systematic Review of Diffusion Tensor Imaging Studies on Neural Connectivity in Autism Spectrum Disorder.Brain sciences · 2025Review
- Contrast subgraphs catch patterns of altered functional connectivity in autism spectrum disorder.Scientific reports · 2025Article
- Improving brain difference identification in autism spectrum disorder through enhanced head motion correction in ICA-AROMA.Communications biology · 2025Article
- Deep learning based joint fusion approach to exploit anatomical and functional brain information in autism spectrum disorders.Brain informatics · 2024Article
- Heterogeneity and convergence across seven neuroimaging modalities: a review of the autism spectrum disorder literature.Frontiers in psychiatry · 2024Review
- Autism Is Associated With Interindividual Variations of Gray and White Matter Morphology.Biological psychiatry. Cognitive neuroscience and neuroimaging · 2023Article
- Linking functional and structural brain organisation with behaviour in autism: a multimodal EU-AIMS Longitudinal European Autism Project (LEAP) study.Molecular autism · 2023Article
- A revisit of the amygdala theory of autism: Twenty years after.Neuropsychologia · 2023Review
- Behavioral and neural underpinnings of empathic characteristics in a Humanitude-care expert.Frontiers in medicine · 2023Article
- Atypically slow processing of faces and non-faces in older autistic adults.Autism : the international journal of research and practice · 2022Article
20 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
12 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Brain tissue changes in autism spectrum disorders seem to be rather subtle and widespread than anatomically distinct. Therefore a multimodal, whole brain imaging technique appears to be an appropriate approach to investigate whether alterations in white and gray matter integrity relate to consistent changes in functional resting state connectivity in individuals with high functioning autism (HFA). We applied diffusion tensor imaging (DTI), voxel-based morphometry (VBM) and resting state functional connectivity magnetic resonance imaging (fcMRI) to assess differences in brain structure and function between 12 individuals with HFA (mean age 35.5, SD 11.4, 9 male) and 12 healthy controls (mean age 33.3, SD 9.0, 8 male). Psychological measures of empathy and emotionality were obtained and correlated with the most significant DTI, VBM and fcMRI findings. We found three regions of convergent structural and functional differences between HFA participants and controls. The right temporo-parietal junction area and the left frontal lobe showed decreased fractional anisotropy (FA) values along with decreased functional connectivity and a trend towards decreased gray matter volume. The bilateral superior temporal gyrus displayed significantly decreased functional connectivity that was accompanied by the strongest trend of gray matter volume decrease in the temporal lobe of HFA individuals. FA decrease in the right temporo-parietal region was correlated with psychological measurements of decreased emotionality. In conclusion, our results indicate common sites of structural and functional alterations in higher order association cortex areas and may therefore provide multimodal imaging support to the long-standing hypothesis of autism as a disorder of impaired higher-order multisensory integration.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.