ArticlePloS one2013
Low Divergence of Clonorchis sinensis in China Based on Multilocus Analysis.
Article in PloS one, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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9 citing papers in PubMed, 21 citations in OpenAlex.
- Genetic Variation and Population Structure ofPathogens (Basel, Switzerland) · 2024Article
- Similarities and differences among the Opisthorchiidae liver flukes: insights fromParasitology · 2022Review
- Liver Fluke Infection Throughout Human Evolution.Gastro hep advances · 2022Review
- Marked mitochondrial genetic variation in individuals and populations of the carcinogenic liver fluke Clonorchis sinensis.PLoS neglected tropical diseases · 2020Article
- Cytochrome C Oxidase Subunit 1, Internal Transcribed Spacer 1, Nicotinamide Adenine Dinucleotide Hydrogen Dehydrogenase Subunits 2 and 5 ofJournal of Korean medical science · 2019Article
- New insights from Opisthorchis felineus genome: update on genomics of the epidemiologically important liver flukes.BMC genomics · 2019Article
- Molecular Identification and Phylogenetic Analysis of Nuclear rDNA Sequences ofFrontiers in microbiology · 2019Article
- The geographical vector in distribution of genetic diversity for Clonorchis sinensis.Parasitology research · 2018Article
- Genome-wide characterization of microsatellites and marker development in the carcinogenic liver fluke Clonorchis sinensis.Parasitology research · 2015Article
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Authors and funding
21 authors at 1 institution in 1 country.
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No grant is acknowledged in the PubMed record.
Abstract
Clonorchis sinensis, an ancient parasite that infects a number of piscivorous mammals, attracts significant public health interest due to zoonotic exposure risks in Asia. The available studies are insufficient to reflect the prevalence, geographic distribution, and intraspecific genetic diversity of C. sinensis in endemic areas. Here, a multilocus analysis based on eight genes (ITS1, act, tub, ef-1a, cox1, cox3, nad4 and nad5 [4.986 kb]) was employed to explore the intra-species genetic construction of C. sinensis in China. Two hundred and fifty-six C. sinensis isolates were obtained from environmental reservoirs from 17 provinces of China. A total of 254 recognized Multilocus Types (MSTs) showed high diversity among these isolates using multilocus analysis. The comparison analysis of nuclear and mitochondrial phylogeny supports separate clusters in a nuclear dendrogram. Genetic differentiation analysis of three clusters (A, B, and C) showed low divergence within populations. Most isolates from clusters B and C are geographically limited to central China, while cluster A is extraordinarily genetically diverse. Further genetic analyses between different geographic distributions, water bodies and hosts support the low population divergence. The latter haplotype analyses were consistent with the phylogenetic and genetic differentiation results. A recombination network based on concatenated sequences showed a concentrated linkage recombination population in cox1, cox3, nad4 and nad5, with spatial structuring in ITS1. Coupled with the history record and archaeological evidence of C. sinensis infection in mummified desiccated feces, these data point to an ancient origin of C. sinensis in China. In conclusion, we present a likely phylogenetic structure of the C. sinensis population in mainland China, highlighting its possible tendency for biogeographic expansion. Meanwhile, ITS1 was found to be an effective marker for tracking C. sinensis infection worldwide. Thus, the present study improves our understanding of the global epidemiology and evolution of C. sinensis.
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