ArticlePloS one2013
High cholesterol diet induces IL-1β expression in adult but not larval zebrafish.
Article in PloS one, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
15 citing papers in PubMed, 29 citations in OpenAlex.
- Histological Divergence Underlying Globular Body Shapes in Ornamental Goldfish.Zoological studies · 2026Article
- Current status and challenges of multi-omics research using animal models of atherosclerosis.Journal of molecular and cellular cardiology plus · 2025Review
- Comparative Assessment of Beeswax Alcohol and Coenzyme QPharmaceuticals (Basel, Switzerland) · 2024Article
- Biological toxicity of sulfamethoxazole in aquatic ecosystem on adult zebrafish (Danio rerio).Scientific reports · 2024Article
- Oridonin supplementation attenuates atherosclerosis via NLRP-3 inflammasome pathway suppression.Journal of medicine and life · 2023Article
- Protective mechanisms of a microbial oil against hypercholesterolemia: evidence from a zebrafish model.Frontiers in nutrition · 2023Article
- Management of Hypercholesterolemia Through Dietary ß-glucans-Insights From a Zebrafish Model.Frontiers in nutrition · 2021Article
- Evidence for host effect on the intestinal microbiota of whitefish (Ecology and evolution · 2019Article
- Current basis and future directions of zebrafish nutrigenomics.Genes & nutrition · 2019Review
- Obese zebrafish: A small fish for a major human health condition.Animal models and experimental medicine · 2018Review
- Holobionts and ecological speciation: the intestinal microbiota of lake whitefish species pairs.Microbiome · 2018Article
- ModelingJournal of cardiovascular development and disease · 2016Article
- Retinol-binding protein 4 and its potential roles in hypercholesterolemia revealed by proteomics.EXCLI journal · 2015Article
- Application of chrysophanol in zebrafish to reduce dietary introduced lipid and its possible mechanism.International journal of clinical and experimental medicine · 2015Article
- Zebrafish models of dyslipidemia: relevance to atherosclerosis and angiogenesis.Translational research : the journal of laboratory and clinical medicine · 2014Review
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Recently, it has been demonstrated that high cholesterol diet induced hypercholesterolemia and vascular lipid oxidation and accumulation in zebrafish larvae, suggesting that zebrafish is a new promising atherosclerosis model in addition to mouse models. However, up to date, there was no report regarding inflammatory cytokine expression during the lipid accumulation in zebrafish larva and adult fish. In this study, we first demonstrated the expression levels of IL-1β and TNF-α in high cholesterol diet (HCD)-fed zebrafish larvae, and found that although HCD induced vascular lipid accumulation, the cytokine expressions in the larvae were not changed by HCD. Furthermore, there was no significant difference in leukocyte accumulation in vessels between control and HCD fed group. But prolonged HCD induced IL-1β expression in spleen and liver compared to those of control zebrafish, and produced very early stage of fatty streak lesion in dorsal aorta of 19 week HCD-fed zebrafish. These results indicate that HCD induced hypercholesterolemia and atherosclerotic changes in zebrafish are very early stage, and suggest the necessity of the generation of mutant zebrafish having a disruption in a lipid metabolism-related gene leading to severe hypercholesterolemia and advanced atherosclerosis.
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Registered trials
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