Trial reportThe Journal of neuroscience : the official journal of the Society for Neuroscience2013
A functionally guided approach to the morphometry of occipitotemporal regions in developmental dyslexia: evidence for differential effects in boys and girls.
Trial report in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
33 citing papers in PubMed, 2 syntheses or guidelines pooled it, 72 citations in OpenAlex.
- Orthographic depth and developmental dyslexia: a meta-analytic study.Annals of dyslexia · 2021Pooled it
- Pooled it
- Agreement between FreeSurfer and CAT12 Cortical Thickness Measurements: A Discovery and a Replication Study in Children/Adolescents.Brain topography · 2026Article
- Neural Mechanisms Underlying Reading Impairment in Children Learning a Second Language: A Review.Behavioral sciences (Basel, Switzerland) · 2025Review
- Sex Differences in White Matter Diffusivity in Children with Developmental Dyslexia.Children (Basel, Switzerland) · 2024Article
- Neural dissociation of visual attention span and phonological deficits in developmental dyslexia: A hub-based white matter network analysis.Human brain mapping · 2022Article
- Investigating the association between variability in sulcal pattern and academic achievement.Scientific reports · 2022Article
- The Role of Brain Activity in Characterizing Successful Reading Intervention in Children With Dyslexia.Frontiers in neuroscience · 2022Article
- Words as Visual Objects: Neural and Behavioral Evidence for High-Level Visual Impairments in Dyslexia.Brain sciences · 2021Review
- Functional and morphological correlates of developmental dyslexia: A multimodal investigation of the ventral occipitotemporal cortex.Journal of neuroimaging : official journal of the American Society of Neuroimaging · 2021Article
- Voxel and surface based whole brain analysis shows reading skill associated grey matter abnormalities in dyslexia.Scientific reports · 2021Article
- How to capture developmental brain dynamics: gaps and solutions.NPJ science of learning · 2021Article
- Article
- The relationship between brain structure and proficiency in reading and mathematics in children, adolescents, and emerging adults.Developmental cognitive neuroscience · 2020Article
- Shared Neural Substrates Underlying Reading and Visual Matching: A Longitudinal Investigation.Frontiers in human neuroscience · 2020Article
- Reading Acquisition in Children: Developmental Processes and Dyslexia-Specific Effects.Journal of the American Academy of Child and Adolescent Psychiatry · 2019Article
- Relationships between gray matter volume and reading ability in typically developing children, adolescents, and young adults.Developmental cognitive neuroscience · 2019Article
- White matter network connectivity deficits in developmental dyslexia.Human brain mapping · 2019Article
- The neuronal migration hypothesis of dyslexia: A critical evaluation 30 years on.The European journal of neuroscience · 2018Review
- Alterations in white matter pathways underlying phonological and morphological processing in Chinese developmental dyslexia.Developmental cognitive neuroscience · 2018Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 5 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Developmental dyslexia is a learning disability that specifically affects reading acquisition. Cortical anomalies and gray matter volume differences in various temporal regions have been reported in dyslexic subjects compared with controls. However, consistency between studies is lacking. In the present experiments, we focused our structural analyses on the ventral occipitotemporal regions, defined by their functional response to visual categories. We applied a subject-by-subject functionally guided approach on a total of 76 participants (31 dyslexic children). Cortical thickness was estimated for each participant around his/her peak of specific functional activation to visual words, faces, or places. Results from two independent datasets showed a reduction in thickness in dyslexic children compared with controls in the region responsive to words, in the left hemisphere. Additionally, a gender-by-diagnosis interaction was observed at the same location, due to differences in girls only. To avoid the potential confound of reading level, we also contrasted dyslexic and control children matched for reading performance, and we observed a similar difference, although in a smaller extent of cortex. The present study thus provides the first account of a focal cortical thickness reduction in dyslexia in the subregion of ventral occipitotemporal cortex specifically responsive to visual words, when age, gender, and reading performance are taken into account.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.