ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2013
An essential role for inhibitor-2 regulation of protein phosphatase-1 in synaptic scaling.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed, 31 citations in OpenAlex.
- Convergence and divergence of molecular mechanisms in Hebbian and homeostatic plasticity.Frontiers in synaptic neuroscience · 2026Review
- Distinct PKA Signaling in Cytosolic and Mitochondrial Compartments in Electrically Paced Atrial Myocytes.Cells · 2022Article
- Protein phosphatase-1 inhibitor-2 promotes PP1Frontiers in synaptic neuroscience · 2022Article
- Memory destabilization during reconsolidation: a consequence of homeostatic plasticity?Learning & memory (Cold Spring Harbor, N.Y.) · 2021Article
- Regulation of Synaptic Transmission and Plasticity by Protein Phosphatase 1.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2021Review
- Relocation of an Extrasynaptic GABANeuron · 2021Article
- Article
- The AMPA Receptor Code of Synaptic Plasticity.Neuron · 2018Review
- Distinct Roles of Protein Phosphatase 1 Bound on Neurabin and Spinophilin and Its Regulation in AMPA Receptor Trafficking and LTD Induction.Molecular neurobiology · 2018Article
- Bipolar disorder with binge eating behavior: a genome-wide association study implicates PRR5-ARHGAP8.Translational psychiatry · 2018Article
- CaThe EMBO journal · 2018Article
- Stargazin Dephosphorylation Mediates Homeostatic Synaptic Downscaling of Excitatory Synapses.Frontiers in molecular neuroscience · 2018Article
- Tracking the Fragile X Mental Retardation Protein in a Highly Ordered Neuronal RiboNucleoParticles Population: A Link between Stalled Polyribosomes and RNA Granules.PLoS genetics · 2016Article
- Emerging Link between Alzheimer's Disease and Homeostatic Synaptic Plasticity.Neural plasticity · 2016Review
- Coordination of Protein Phosphorylation and Dephosphorylation in Synaptic Plasticity.The Journal of biological chemistry · 2015Review
- Protein Phosphatase-1 Inhibitor-2 Is a Novel Memory Suppressor.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2015Article
- Potassium channel Kv2.1 is regulated through protein phosphatase-1 in response to increases in synaptic activity.Neuroscience letters · 2014Article
- The Rac1 inhibitor NSC23766 suppresses CREB signaling by targeting NMDA receptor function.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2014Article
- Microcystins alter chemotactic behavior in Caenorhabditis elegans by selectively targeting the AWA sensory neuron.Toxins · 2014Article
- Molecular mechanisms of homeostatic synaptic downscaling.Neuropharmacology · 2014Review
Corrections and comments
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Authors and funding
7 authors at 4 institutions in 2 countries.
Funding
Abstract
Protein phosphatase-1 (PP1) activity is important for many calcium-dependent neuronal functions including Hebbian synaptic plasticity and learning and memory. PP1 activity is necessary for the induction of long-term depression, whereas downregulation of PP1 activity is required for the normal induction of long-term potentiation. However, how PP1 is activated is not clear. Moreover, it is not known whether PP1 plays a role in homeostatic synaptic scaling, another form of synaptic plasticity which functions to reset the neuronal firing rate in response to chronic neuronal activity perturbations. In this study, we found that PP1 inhibitor-2 (I-2) is phosphorylated at serine 43 (S43) in rat and mouse cortical neurons in response to bicuculine application. Expression of I-2 phosphorylation-blocking mutant I-2 (S43A) blocked the dephosphorylation of GluA2 at serine 880, AMPA receptor trafficking, and synaptic downscaling induced by bicuculline application. Our data suggest that the phosphorylation of I-2 at S43 appears to be mediated by L-type calcium channels and calcium/calmodulin-dependent myosin light-chain kinase. Our work thus reveals a novel calcium-induced PP1 activation pathway critical for homeostatic synaptic plasticity.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.