Trial reportThe Journal of neuroscience : the official journal of the Society for Neuroscience2013
Neural correlates of short-term memory reorganization in humans with hippocampal damage.
Trial report in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
17 citing papers in PubMed, 42 citations in OpenAlex.
- Cortico-hippocampal networks underpin verbal memory encoding in temporal lobe epilepsy.Brain communications · 2025Article
- Structural changes of CA1 pyramidal neurons after stroke in the contralesional hippocampus.Brain pathology (Zurich, Switzerland) · 2024Article
- Multisensory input modulates memory-guided spatial navigation in humans.Communications biology · 2023Article
- Intact high-resolution working memory binding in a patient with developmental amnesia and selective hippocampal damage.Hippocampus · 2022Article
- Altered hippocampal-prefrontal functional network integrity in adult macaque monkeys with neonatal hippocampal lesions.NeuroImage · 2021Article
- Genes associated with cognitive performance in the Morris water maze: an RNA-seq study.Scientific reports · 2020Article
- Structural plasticity of the hippocampus in response to estrogens in female rodents.Molecular brain · 2019Review
- Association of Visual Impairment in Neuromyelitis Optica Spectrum Disorder With Visual Network Reorganization.JAMA neurology · 2018Article
- Memory profiles in Down syndrome across development: a review of memory abilities through the lifespan.Journal of neurodevelopmental disorders · 2018Review
- Hippocampal functional connectivity is related to self-reported cognitive concerns in breast cancer patients undergoing adjuvant therapy.NeuroImage. Clinical · 2018Article
- Neuropsychological Profiles Differentiate Alzheimer Disease from Subcortical Ischemic Vascular Dementia in an Autopsy-Defined Cohort.Dementia and geriatric cognitive disorders · 2017Article
- Causes and consequences of limitations in visual working memory.Annals of the New York Academy of Sciences · 2016Review
- Working Memory Network Changes in ALS: An fMRI Study.Frontiers in neuroscience · 2016Article
- Binding in working memory and frontal lobe in normal aging: is there any similarity with autism?Frontiers in human neuroscience · 2015Article
- Targeted enhancement of cortical-hippocampal brain networks and associative memory.Science (New York, N.Y.) · 2014Article
- Aberrant functional connectivity in dissociable hippocampal networks is associated with deficits in memory.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2014Article
- Short-term retention of relational memory in amnesia revisited: accurate performance depends on hippocampal integrity.Frontiers in human neuroscience · 2014Article
Corrections and comments
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Authors and funding
5 authors at 3 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Some patients with disorders affecting the hippocampus have relatively intact memory, but the mechanisms underlying this preservation of function are still debated. In particular, it is unclear whether preserved memory is attributable to significant residual function of unaffected hippocampus or to functional brain reorganization. Here, we investigated brain activation during an associative short-term memory task in two human patient groups matched for extent of postsurgical damage to the right hippocampal formation that differed in two key features, memory performance and preoperative disease course. Patients showed strikingly distinct activation patterns that correlated differentially with behavioral performance, strongly suggesting that intact associative short-term memory with hippocampal dysfunction is indeed related to compensatory brain reorganization. This process appears to depend both on activation of the contralesional hippocampus and on increased engagement of a distributed short-term memory network in neocortex. These data clarify the existence of an efficient hippocampal-neocortical mechanism that compensates for hippocampal dysfunction.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.