ArticleCerebral cortex (New York, N.Y. : 1991)2014
Convergence of cortical and sensory driver inputs on single thalamocortical cells.
Article in Cerebral cortex (New York, N.Y. : 1991), 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 102 papers.
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102 citing papers in PubMed, 235 citations in OpenAlex.
- RIFT: A Fractal-Holographic Theory of Consciousness and Autopoietic Control.Brain sciences · 2026Article
- The role of transthalamic pathways in perception.Communications biology · 2026Review
- Modulation and Gating of Transthalamic and Subcortical Pathways through Somatosensory Thalamus.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2026Article
- Ascending and descending motor pathways converge in the centrolateral nucleus of the thalamus.Research square · 2026Article
- Somatosensory control of thalamic relay neurons is regulated by two distinct layer 6 feedback systems.iScience · 2026Article
- Individual Pulvinar Neurons Integrate Cortical and Subcortical Signals.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2026Article
- Layer 5 myelination gates corticothalamic coincidence detection.Nature communications · 2025Article
- Pathway-Specific Ultrastructure of Thalamocortical Synapses in Mouse Somatosensory Area S2.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025Article
- Convergence and Segregation of Excitatory and Inhibitory Afferents in the Paraventricular Thalamic Nucleus.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025Article
- Role of posterior medial thalamus in the modulation of striatal circuitry and choice behavior.eLife · 2025Article
- The spatial extent of anatomical connections within the thalamus varies across the cortical hierarchy in humans and macaques.bioRxiv : the preprint server for biology · 2025Article
- The reuniens nucleus of the thalamus facilitates hippocampo-cortical dialogue during sleep.eLife · 2025Article
- A cortico-subcortical loop for motor control via the pontine reticular formation.Cell reports · 2025Article
- Article
- Attentional modulation of secondary somatosensory and visual thalamus of mice.bioRxiv : the preprint server for biology · 2024Article
- Beyond Barrels: Diverse Thalamocortical Projection Motifs in the Mouse Ventral Posterior Complex.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2024Article
- Transthalamic Pathways for Cortical Function.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2024Review
- A transthalamic pathway crucial for perception.Nature communications · 2024Article
- Co-coding of head and whisker movements by both VPM and POm thalamic neurons.Nature communications · 2024Article
- Development of reciprocal connections between the dorsal lateral geniculate nucleus and the thalamic reticular nucleus.Neural development · 2024Article
42 more citing papers are in PubMed but not listed here.
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8 authors at 4 institutions in 3 countries.
Funding
Abstract
Ascending and descending information is relayed through the thalamus via strong, "driver" pathways. According to our current knowledge, different driver pathways are organized in parallel streams and do not interact at the thalamic level. Using an electron microscopic approach combined with optogenetics and in vivo physiology, we examined whether driver inputs arising from different sources can interact at single thalamocortical cells in the rodent somatosensory thalamus (nucleus posterior, POm). Both the anatomical and the physiological data demonstrated that ascending driver inputs from the brainstem and descending driver inputs from cortical layer 5 pyramidal neurons converge and interact on single thalamocortical neurons in POm. Both individual pathways displayed driver properties, but they interacted synergistically in a time-dependent manner and when co-activated, supralinearly increased the output of thalamus. As a consequence, thalamocortical neurons reported the relative timing between sensory events and ongoing cortical activity. We conclude that thalamocortical neurons can receive 2 powerful inputs of different origin, rather than only a single one as previously suggested. This allows thalamocortical neurons to integrate raw sensory information with powerful cortical signals and transfer the integrated activity back to cortical networks.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.