ArticleCancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology2013
Decisional outcomes of maternal disclosure of BRCA1/2 genetic test results to children.
Article in Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 1 of them a synthesis that pooled it.
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Who cites it
19 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Family Communication, Risk Perception and Cancer Knowledge of Young Adults from BRCA1/2 Families: a Systematic Review.Journal of genetic counseling · 2017Pooled it
- Maternal Communication of BRCA Risk to Adolescent and Young Adult Children: Implications for Supportive Care Intervention.Psycho-oncology · 2026Article
- Patient perspectives after receiving simulated preconception polygenic risk scores (PRS) for family planning.Journal of assisted reproduction and genetics · 2025Article
- Effects of personal cancer history and genomic risk information on mothers' psychological adaptation to inherited breast/ovarian cancer syndrome.Psychology, health & medicine · 2025Article
- Parental Understanding of Their Child's Germline Genomic Testing: Intent of Disclosure to Their Child and Family.Journal of personalized medicine · 2023Article
- Long-Term Adaptation Among Adolescent and Young Adult Children to Familial Cancer Risk.Pediatrics · 2022Article
- The big reveal: Family disclosure patterns of BRCA genetic test results among young Black women with invasive breast cancer.Journal of genetic counseling · 2020Article
- Cancer genetic health communication in families tested for hereditary breast/ovarian cancer risk: a qualitative investigation of impact on children's genetic health literacy and psychosocial adjustment.Translational behavioral medicine · 2019Article
- Children's Knowledge about Parental Exposure to Trauma.Journal of child & adolescent trauma · 2019Article
- Preventative Health and Risk Behaviors Among Adolescent Girls With and Without Family Histories of Breast Cancer.The Journal of adolescent health : official publication of the Society for Adolescent Medicine · 2019Article
- Maternal perceptions of BRCA genetic counseling communication processes about disclosing cancer risk information to children and adult relatives.Psycho-oncology · 2018Article
- Development of a Tool to Guide Parents Carrying a BRCA1/2 Mutation Share Genetic Results with Underage Children.Journal of cancer education : the official journal of the American Association for Cancer Education · 2018Article
- The challenges of the expanded availability of genomic information: an agenda-setting paper.Journal of community genetics · 2018Article
- Modeling the dyadic effects of parenting, stress, and coping on parent-child communication in families tested for hereditary breast-ovarian cancer risk.Familial cancer · 2016Article
- Psychosocial Adjustment and Perceived Risk Among Adolescent Girls From Families With BRCA1/2 or Breast Cancer History.Journal of clinical oncology : official journal of the American Society of Clinical Oncology · 2016Article
- Understanding the Needs of Young Women Regarding Breast Cancer Risk Assessment and Genetic Testing: Convergence and Divergence among Patient-Counselor Perceptions and the Promise of Peer Support.Healthcare (Basel, Switzerland) · 2016Article
- Psychosocial Adjustment in School-age Girls With a Family History of Breast Cancer.Pediatrics · 2015Article
- In response to Peshkin et al. "Genetic counseling and testing for hereditary cancer risk in young adult women: Facilitating autonomy and informed decision making is key".Gynecologic oncology reports · 2015Article
- Women's concerns about the emotional impact of awareness of heritable breast cancer risk and its implications for their children.Journal of community genetics · 2015Article
Corrections and comments
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Authors and funding
8 authors.
Funding
Abstract
backgroundAlthough BRCA1/2 genetic testing is discouraged in minors, mothers may disclose their own results to their children. Factors affecting patients' disclosure decisions and patient outcomes of disclosure are largely unknown.
methodsMothers (N = 221) of children aged 8 to 21 years enrolled in this prospective study of family communication about cancer genetic testing. Patients underwent BRCA1/2 genetic counseling and testing, and completed standardized behavioral assessments before and 1-month following receipt of their results.
resultsMost patients (62.4%) disclosed BRCA1/2 test results to their child. Patients were more likely to disclose if they received negative or uninformative versus positive results [OR = 3.11; 95% confidence interval (CI), 1.11-8.71; P = .03], their child was 13 years of age or more versus younger (OR = 5.43; 95% CI, 2.18-13.53; P < .001), and as the ratio of patients' perceived benefits of disclosure outweighed potential risks (OR = 2.40; 95% CI, 1.63-3.54; P < .001). Postdecision satisfaction about disclosure was lowest among nondisclosing patients (P < .001) and those reporting greater decisional conflict (P < .001).
conclusionsPatients commonly discuss their BRCA1/2 results with their teenage and young adult children, especially if the information is perceived as beneficial. Satisfaction with disclosure decision making remains lowest among nondisclosing and conflicted patients. Family communication decision support adjuncts to genetic counseling are needed to help ameliorate these effects. IMPACT: This study describes the prevalence of family communication about maternal BRCA1/2 genetic testing with minor children, and decisions and outcomes of disclosure.
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