Evidence map›Paper›PMID 23825169›Full record

ArticleAmerican journal of epidemiology2013

Is the observed association between dairy intake and fibroids in African Americans explained by genetic ancestry?

Lauren A Wise, Julie R Palmer, Edward Ruiz-Narvaez, David E Reich, Lynn Rosenberg

Open access · greenAbstract read
In one paragraph

Article in American journal of epidemiology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
2.4field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 20 citations in OpenAlex.

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  12. Epidemiology of Uterine Myomas: A Review.International journal of fertility & sterility
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Lauren A Wise
Julie R Palmer
Edward Ruiz-Narvaez
David E Reich
Lynn Rosenberg

Funding

FOLLOW-UP STUDY FOR CAUSES OF ILLNESS IN BLACK WOMENR01CA058420 · NCI · BOSTON UNIVERSITY MEDICAL CAMPUS · PI ROSENBERG, LYNN · 1999 to 2013
$20.7M
A Follow-up Study for Causes of Cancer in Black WomenUM1CA164974 · NCI · BOSTON UNIVERSITY MEDICAL CAMPUS · PI ROSENBERG, LYNN · 2012 to 2017
$13.7M
Genetic Admixture Study of Uterine Fibroids in African American WomenR01HD057966 · NICHD · BOSTON UNIVERSITY MEDICAL CAMPUS · PI WISE, LAUREN A · 2009 to 2012
$2.0M
A Prospective Study of Diet and Fibroids in Black WomenR03HD055211 · NICHD · BOSTON UNIVERSITY MEDICAL CAMPUS · PI WISE, LAUREN A · 2008 to 2009
$124k
NCI NIH HHS CA58420NCI NIH HHS R01 CA058420NCI NIH HHS UM1 CA164974NICHD NIH HHS HD055211NICHD NIH HHS R01 HD057966NICHD NIH HHS R01HD057966NICHD NIH HHS R03 HD055211
6 · The paper itself

Abstract

Uterine leiomyomata are a major source of gynecological morbidity and are 2-3 times more prevalent in African Americans than European Americans. In an earlier report, we found that dairy intake was inversely associated with uterine leiomyomata among African Americans. Because African Americans are more likely to have lactose intolerance and avoid dairy products, the observed association might have been confounded by genetic ancestry. This report reevaluates the dairy-uterine leiomyomata association after accounting for genetic ancestry among 1,968 cases and 2,183 noncases from the Black Women's Health Study (1997-2007). Dairy intake was estimated by using food frequency questionnaires in 1995 and 2001. Percent European ancestry was estimated by using a panel of ancestry informative markers. Incidence rate ratios and 95% confidence intervals were estimated by using Cox regression, with adjustment for potential confounders and percent European ancestry. Incidence rate ratios comparing 1, 2, 3, and ≥4 servings/day with <1 serving/day of dairy products were 0.95 (95% confidence interval (CI): 0.85, 1.06), 0.75 (95% CI: 0.61, 0.92), 0.77 (95% CI: 0.57, 1.04), and 0.59 (95% CI: 0.41, 0.86), respectively (Ptrend = 0.0003). These effect estimates were similar to those obtained without control for ancestry. The findings suggest that the observed inverse association between dairy consumption and uterine leiomyomata in African Americans is not explained by percent European ancestry.

Indexed as

Black or African AmericanAdultDairy ProductsFemaleGenetic Predisposition to DiseaseHumansLeiomyomaMiddle AgedPrevalenceRisk FactorsUnited StatesUterine NeoplasmsAfrican Americansdairy productsgenetic ancestryleiomyomaprospective studies

Identifiers

PMID23825169
PMCPMC3857926
OpenAlexW2102474095

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.