ArticleJournal of the Royal Society, Interface2013
Minimizing the risk of cancer: tissue architecture and cellular replication limits.
Article in Journal of the Royal Society, Interface, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
19 citing papers in PubMed.
- Minimising mutation load as a mechanism for low-dose hyper-radiosensitivity and induced radioresistance.Scientific reports · 2026Article
- Modeling the evolutionary dynamics of clonal hematopoiesis.Nature genetics · 2026Review
- Constrained optimization of divisional load in hierarchically organized tissues during homeostasis.Journal of the Royal Society, Interface · 2022Article
- Differentiation of leukemic blasts is not completely blocked in acute myeloid leukemia.Proceedings of the National Academy of Sciences of the United States of America · 2019Article
- The invasion of de-differentiating cancer cells into hierarchical tissues.PLoS computational biology · 2019Article
- The role of telomere shortening in carcinogenesis: A hybrid stochastic-deterministic approach.Journal of theoretical biology · 2019Article
- Variation of mutational burden in healthy human tissues suggests non-random strand segregation and allows measuring somatic mutation rates.PLoS computational biology · 2018Article
- Adaptive self-organization in the embryo: its importance to adult anatomy and to tissue engineering.Journal of anatomy · 2018Review
- Optimizing homeostatic cell renewal in hierarchical tissues.PLoS computational biology · 2018Article
- Clonal dominance and transplantation dynamics in hematopoietic stem cell compartments.PLoS computational biology · 2017Article
- Should tissue structure suppress or amplify selection to minimize cancer risk?Biology direct · 2016Article
- The Cancer Stem Cell Fraction in Hierarchically Organized Tumors Can Be Estimated Using Mathematical Modeling and Patient-Specific Treatment Trajectories.Cancer research · 2016Article
- Wide-field tissue polarimetry allows efficient localized mass spectrometry imaging of biological tissues.Chemical science · 2016Article
- Quantifying replicative senescence as a tumor suppressor pathway and a target for cancer therapy.Scientific reports · 2015Article
- Reconstructing the in vivo dynamics of hematopoietic stem cells from telomere length distributions.eLife · 2015Article
- Toward an evolutionary model of cancer: Considering the mechanisms that govern the fate of somatic mutations.Proceedings of the National Academy of Sciences of the United States of America · 2015Article
- Preventing clonal evolutionary processes in cancer: Insights from mathematical models.Proceedings of the National Academy of Sciences of the United States of America · 2015Article
- A multicompartment mathematical model of cancer stem cell-driven tumor growth dynamics.Bulletin of mathematical biology · 2014Article
- Robustness of differentiation cascades with symmetric stem cell division.Journal of the Royal Society, Interface · 2014Article
Corrections and comments
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Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Normal somatic cells are capable of only a limited number of divisions, which prevents unlimited cell proliferation and the onset of tumours. Cancer cells find ways to circumvent this obstacle, typically by expressing the enzyme telomerase and less often by alternative recombination strategies. Given this fundamental link between cellular replication limits and cancer, it is important to understand how a tissue's architecture affects the replicative capacity of a cell population. We define this as the average number of remaining divisions at equilibrium. The lower the replication capacity, the lower the chances to escape the replication limit during abnormal growth when a tumour develops. In this paper, we examine how the replication capacity is influenced by defining characteristics of cell lineages, such as the number of intermediate cell compartments, self-renewal capability of cells and division rates. We describe an optimal tissue architecture that minimizes the replication capacity of dividing cells and thus the risk of cancer. Interestingly, some of the features that define an optimal tissue architecture have been documented in a variety of tissues, suggesting that they may have evolved as a cancer-protecting strategy in multicellular organisms.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.