ArticleAmerican journal of physiology. Renal physiology2013
Blood pressure-renal blood flow relationships in conscious angiotensin II- and phenylephrine-infused rats.
Article in American journal of physiology. Renal physiology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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17 citing papers in PubMed, 26 citations in OpenAlex.
- Effect of continuous intraoperative infusion of methoxamine on renal function in elderly patients undergoing gastrointestinal tumor surgery: a randomized controlled trial.BMC anesthesiology · 2020Trial
- Novel soluble guanylyl cyclase activators increase glomerular cGMP, induce vasodilation and improve blood flow in the murine kidney.British journal of pharmacology · 2022Article
- Impact ofMicroorganisms · 2021Review
- Salt-Sensitive Hypertension, Renal Injury, and Renal Vasodysfunction Associated With Dahl Salt-Sensitive Rats Are Abolished in Consomic SS.BN1 Rats.Journal of the American Heart Association · 2021Article
- Kidney and epigenetic mechanisms of salt-sensitive hypertension.Nature reviews. Nephrology · 2021Review
- Role of Rho in Salt-Sensitive Hypertension.International journal of molecular sciences · 2021Review
- Degree of blood pressure control and the risk of new-onset hyperuricemia in treated hypertensive patients.Annals of translational medicine · 2020Article
- Salt causes aging-associated hypertension via vascular Wnt5a under Klotho deficiency.The Journal of clinical investigation · 2020Article
- BP Fluctuations and the Real-Time Dynamics of Renal Blood Flow Responses in Conscious Rats.Journal of the American Society of Nephrology : JASN · 2020Article
- Pharmacological inhibition of TRPV4 channels protects against ischemia-reperfusion-induced renal insufficiency in neonatal pigs.Clinical science (London, England : 1979) · 2019Article
- Angiotensin II-induced hypertension in rats is only transiently accompanied by lower renal oxygenation.Scientific reports · 2018Article
- Exogenous and endogenous angiotensin-II decrease renal cortical oxygen tension in conscious rats by limiting renal blood flow.The Journal of physiology · 2016Article
- Modulation of the myogenic mechanism: concordant effects of NO synthesis inhibition and O2- dismutation on renal autoregulation in the time and frequency domains.American journal of physiology. Renal physiology · 2016Article
- Glomerulosclerosis in the diet-induced obesity model correlates with sensitivity to nitric oxide inhibition but not glomerular hyperfiltration or hypertrophy.American journal of physiology. Renal physiology · 2015Article
- Isoform-specific dynamic translocation of PKC by α1-adrenoceptor stimulation in live cells.Biochemical and biophysical research communications · 2015Article
- Renal autoregulation in health and disease.Physiological reviews · 2015Review
- Hemodynamic basis for the limited renal injury in rats with angiotensin II-induced hypertension.American journal of physiology. Renal physiology · 2015Article
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5 authors at 2 institutions in 1 country.
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Abstract
Chronic ANG II infusion in rodents is widely used as an experimental model of hypertension, yet very limited data are available describing the resulting blood pressure-renal blood flow (BP-RBF) relationships in conscious rats. Accordingly, male Sprague-Dawley rats (n = 19) were instrumented for chronic measurements of BP (radiotelemetry) and RBF (Transonic Systems, Ithaca, NY). One week later, two or three separate 2-h recordings of BP and RBF were obtained in conscious rats at 24-h intervals, in addition to separate 24-h BP recordings. Rats were then administered either ANG II (n = 11, 125 ng·kg(-1)·min(-1)) or phenylephrine (PE; n = 8, 50 mg·kg(-1)·day(-1)) as a control, ANG II-independent, pressor agent. Three days later the BP-RBF and 24-h BP recordings were repeated over several days. Despite similar increases in BP, PE led to significantly greater BP lability at the heart beat and very low frequency bandwidths. Conversely, ANG II, but not PE, caused significant renal vasoconstriction (a 62% increase in renal vascular resistance and a 21% decrease in RBF) and increased variability in BP-RBF relationships. Transfer function analysis of BP (input) and RBF (output) were consistent with a significant potentiation of the renal myogenic mechanism during ANG II administration, likely contributing, in part, to the exaggerated reductions in RBF during periods of BP elevations. We conclude that relatively equipressor doses of ANG II and PE lead to greatly different ambient BP profiles and effects on the renal vasculature when assessed in conscious rats. These data may have important implications regarding the pathogenesis of hypertension-induced injury in these models of hypertension.
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