ArticleJournal of virology2013
Involvement of the reparative DNA polymerase Pol X of African swine fever virus in the maintenance of viral genome stability in vivo.
Article in Journal of virology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 33 citations in OpenAlex.
- Insights and progress on epidemic characteristics, pathogenesis, and preventive measures of African swine fever virus: A review.Virulence · 2025Review
- Article
- Structural and Evolutionary Analysis of Proteins Endowed with a Nucleotidyltransferase, or Non-canonical Palm, Catalytic Domain.Journal of molecular evolution · 2024Article
- Generation and Genetic Stability of a PolX and 5' MGF-Deficient African Swine Fever Virus Mutant for Vaccine Development.Vaccines · 2024Article
- The Production of Recombinant African Swine Fever Virus Lv17/WB/Rie1 Strains and Their In Vitro and In Vivo Characterizations.Vaccines · 2023Article
- African swine fever virus - variants on the rise.Emerging microbes & infections · 2023Article
- Brincidofovir is a robust replication inhibitor against African swine fever virusEmerging microbes & infections · 2023Article
- Article
- Polygalic acid inhibits african swine fever virus polymerase activity: findings from machine learning and in vitro testing.Journal of computer-aided molecular design · 2023Article
- Comparative genomic and transcriptomic analyses of African swine fever virus strains.Computational and structural biotechnology journal · 2023Article
- Review
- Crystal Structure of African Swine Fever Virus pS273R Protease and Implications for Inhibitor Design.Journal of virology · 2020Article
- A unique DNA-binding mode of African swine fever virus AP endonuclease.Cell discovery · 2020Article
- The unique genetic variation within the O174L gene of Polish strains of African swine fever virus facilitates tracking virus origin.Archives of virology · 2019Article
- African swine fever virus evasion of host defences.Virus research · 2019Review
- The first complete genomic sequences of African swine fever virus isolated in Poland.Scientific reports · 2019Article
- Intra-epidemic genome variation in highly pathogenic African swine fever virus (ASFV) from the country of Georgia.Virology journal · 2018Article
- A Proteomic Atlas of the African Swine Fever Virus Particle.Journal of virology · 2018Article
- Phaeocystis globosa Virus DNA Polymerase X: a "Swiss Army knife", Multifunctional DNA polymerase-lyase-ligase for Base Excision Repair.Scientific reports · 2017Article
- Genome Sequence of African Swine Fever Virus BA71, the Virulent Parental Strain of the Nonpathogenic and Tissue-Culture Adapted BA71V.PloS one · 2015Article
Corrections and comments
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Authors and funding
5 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The function of the African swine fever virus (ASFV) reparative DNA polymerase, Pol X, was investigated in the context of virus infection. Pol X is a late structural protein that localizes at cytoplasmic viral factories during DNA replication. Using an ASFV deletion mutant lacking the Pol X gene, we have shown that Pol X is not required for virus growth in Vero cells or swine macrophages under one-step growth conditions. However, at a low multiplicity of infection, when multiple rounds of replication occur, the growth of the mutant virus is impaired in swine macrophages but not in Vero cells, suggesting that Pol X is needed to repair the accumulated DNA damage. The replication of the mutant virus in Vero cells presents sensitivity to oxidative damage, and mutational analysis of viral DNA shows that deletion of Pol X results in an increase in the mutation frequency in macrophages. Therefore, our data reveal a biological role for ASFV Pol X in the context of the infected cell in the preservation of viral genetic information.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.