ReviewCurrent hypertension reports2013
Role of the carotid body in the pathophysiology of heart failure.
Review in Current hypertension reports, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 44 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
44 citing papers in PubMed, 75 citations in OpenAlex.
- Effects of selective carotid body stimulation with adenosine in conscious humans.The Journal of physiology · 2016Trial
- Consequences of peripheral chemoreflex inhibition with low-dose dopamine in humans.The Journal of physiology · 2014Trial
- Dyspnea in heart failure: pathophysiology, clinical assessment, and evidence from clinical trials.Heart failure reviews · 2026Review
- Genetic deletion of ASIC3 alters left ventricular remodeling and autonomic function after myocardial infarction in mice.Physiological reports · 2026Article
- Genetic Deletion of ASIC3 Alters Left Ventricular Remodeling and Autonomic Function After Myocardial Infarction in Mice.bioRxiv : the preprint server for biology · 2025Article
- Chemoreflex function in pulmonary diseases - A review.The Journal of physiology · 2025Review
- Sympathetic Nervous System in Heart Failure: Targets for Treatments.Current hypertension reports · 2025Review
- Translating physiology of the arterial chemoreflex into novel therapeutic interventions targeting carotid bodies in cardiometabolic disorders.The Journal of physiology · 2025Review
- The effects of P2YFrontiers in physiology · 2023Article
- Carotid Body Dysfunction and Mechanisms of Disease.Advances in anatomy, embryology, and cell biology · 2023Article
- Mechanisms of Chemosensory Transduction in the Carotid Body.Advances in anatomy, embryology, and cell biology · 2023Article
- A Methodological Perspective on the Function and Assessment of Peripheral Chemoreceptors in Heart Failure: A Review of Data from Clinical Trials.Biomolecules · 2022Review
- Obstructive sleep apnea.Handbook of clinical neurology · 2022Review
- The Role of Pharmacological Treatment in the Chemoreflex Modulation.Frontiers in physiology · 2022Review
- CBmeter study: protocol for assessing the predictive value of peripheral chemoreceptor overactivation for metabolic diseases.BMJ open · 2021Article
- Carotid body chemoreceptors: physiology, pathology, and implications for health and disease.Physiological reviews · 2021Review
- Blood Pressure Regulation by the Carotid Sinus Nerve: Clinical Implications for Carotid Body Neuromodulation.Frontiers in neuroscience · 2021Article
- Size of the Carotid Body in Patients with Cardiovascular and Respiratory Diseases Measured by Computed Tomography Angiography: A Case-Control Study.Radiology research and practice · 2021Article
- P2X3 receptor antagonism reduces the occurrence of apnoeas in newborn rats.Respiratory physiology & neurobiology · 2020Article
- Spinal cord neural network interactions: implications for sympathetic control of the porcine heart.American journal of physiology. Heart and circulatory physiology · 2020Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 2 institutions in 1 country.
Funding
Abstract
Important recent advances implicate a role of the carotid body (CB) chemoreflex in sympathetic and breathing dysregulation in several cardio-respiratory diseases, drawing renewed interest in its potential implications for clinical treatment. Evidence from both chronic heart failure (CHF) patients and animal models indicates that the CB chemoreflex is enhanced in CHF, and contributes to the tonic elevation in sympathetic nerve activity (SNA) and periodic breathing associated with the disease. Although this maladaptive change likely derives from altered function at all levels of the reflex arc, a change in afferent function of the CB is likely to be a main driving force. This review will focus on recent advances in our understanding of the pathophysiological mechanisms that alter CB function in CHF and their potential translational impact on treatment of chronic heart failure (CHF).
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.