ArticleBrain : a journal of neurology2013
Comparative semantic profiles in semantic dementia and Alzheimer's disease.
Article in Brain : a journal of neurology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
21 citing papers in PubMed, 57 citations in OpenAlex.
- Semantic control across Alzheimer's disease phenotypes: cognitive mechanisms and neural correlates.Frontiers in aging neuroscience · 2026Article
- Digital assessment of cognition in neurodegenerative disease: a data driven approach leveraging artificial intelligence.Frontiers in psychology · 2024Article
- Semantic item-level metrics relate to future memory decline beyond existing cognitive tests in older adults without dementia.Psychology and aging · 2023Article
- Transcranial Direct Current Stimulation Effects on the Neural Substrate of Conceptual Representations.Brain sciences · 2023Article
- A category-selective semantic memory deficit for animate objects in semantic variant primary progressive aphasia.Brain communications · 2021Article
- On Simulating Neural Damage in Connectionist Networks.Computational brain & behavior · 2020Article
- Article
- Naming and conceptual understanding in frontotemporal dementia.Cortex; a journal devoted to the study of the nervous system and behavior · 2019Article
- Distinctive semantic features in the healthy adult brain.Cognitive, affective & behavioral neuroscience · 2019Article
- Primary Progressive Aphasia and Stroke Aphasia.Continuum (Minneapolis, Minn.) · 2018Review
- Linguistic Aspects of Primary Progressive Aphasia.Annual review of linguistics · 2018Article
- The Differential Contributions of Conceptual Representation Format and Language Structure to Levels of Semantic Abstraction Capacity.Neuropsychology review · 2017Review
- Semantic Feature Training in Combination with Transcranial Direct Current Stimulation (tDCS) for Progressive Anomia.Frontiers in human neuroscience · 2017Article
- Utility of testing for apraxia and associated features in dementia.Journal of neurology, neurosurgery, and psychiatry · 2016Article
- Dissociation of quantifiers and object nouns in speech in focal neurodegenerative disease.Neuropsychologia · 2016Article
- Cognitive and anatomic double dissociation in the representation of concrete and abstract words in semantic variant and behavioral variant frontotemporal degeneration.Neuropsychologia · 2016Article
- The Contribution of Semantic Features to the White Matter Pathways of Tool Processing.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2015Article
- Disorders of representation and control in semantic cognition: Effects of familiarity, typicality, and specificity.Neuropsychologia · 2015Article
- Memory dysfunction.Continuum (Minneapolis, Minn.) · 2015Review
- Differing contributions of inferior prefrontal and anterior temporal cortex to concrete and abstract conceptual knowledge.Cortex; a journal devoted to the study of the nervous system and behavior · 2015Article
Corrections and comments
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Authors and funding
8 authors at 2 institutions in 1 country.
Funding
Abstract
Patients with the semantic variant of primary progressive aphasia, also known as semantic dementia, and Alzheimer's disease have deficits in semantic memory. However, few comparative studies have been performed to determine whether these patient groups have distinct semantic memory impairments. We asked 15 patients with semantic variant primary progressive aphasia and 57 patients with Alzheimer's disease to judge semantic category membership of coloured photos and printed words that are members of familiar natural and manufactured categories, and we related performance to grey matter atrophy. We found that both semantic variant primary progressive aphasia and Alzheimer's disease are significantly impaired on this task. Moreover, patients with semantic variant primary progressive aphasia had a significantly more prominent deficit for natural objects than their own deficit judging manufactured objects. Both semantic variant primary progressive aphasia and Alzheimer's disease had atrophy that included portions of the left temporal lobe. Regression analyses related performance in semantic variant primary progressive aphasia to ventral and medial portions of the left temporal lobe, while regression analyses in Alzheimer's disease related performance to these ventral and medial temporal areas as well as lateral temporal-parietal regions in the left hemisphere. We conclude that both semantic variant primary progressive aphasia and Alzheimer's disease are significantly impaired in a simple category membership judgement task and the selective impairment for natural kinds in semantic variant primary progressive aphasia is related in part to disease in visual association cortex in ventral-medial portions of the left temporal lobe. We discuss factors that may contribute to the semantic memory deficit in semantic variant primary progressive aphasia.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.