ArticleBrain : a journal of neurology2013
Acute lesions that impair affective empathy.
Article in Brain : a journal of neurology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 78 papers, 6 of them syntheses that pooled it.
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Who cites it
78 citing papers in PubMed, 6 syntheses or guidelines pooled it, 151 citations in OpenAlex.
- Empathy in Adults with Acquired Brain Injury: a Systematic Review and Meta-Analysis.Neuropsychology review · 2026Pooled it
- The Role of the Right Language Network and the Multiple-Demand Network in Verbal Semantics: Insights From an Activation Likelihood Estimation Meta-Analysis of 561 Functional Neuroimaging Studies.Human brain mapping · 2025Pooled it
- From risk to chronicity: genetic and neuroimaging insights into the evolving patterns of spontaneous brain activity in schizophrenia.Psychological medicine · 2025Pooled it
- The Company Prosodic Deficits Keep Following Right Hemisphere Stroke: A Systematic Review.Journal of the International Neuropsychological Society : JINS · 2022Pooled it
- Effect of Acupuncture on Neuroplasticity of Stroke Patients with Motor Dysfunction: A Meta-Analysis of fMRI Studies.Neural plasticity · 2021Pooled it
- The right temporoparietal junction in attention and social interaction: A transcranial magnetic stimulation study.Human brain mapping · 2016Pooled it
- Neural effects of oxytocin and mimicry in frontotemporal dementia: A randomized crossover study.Neurology · 2020Trial
- Neonatal brain structure, cognitively stimulating parenting and behavioural outcomes in preschool children with congenital heart disease and controls.Scientific reports · 2026Article
- Empathy motivation is preserved following amygdala damage.Brain : a journal of neurology · 2026Article
- Harnessing the Neurobiology of Empathy and Compassion to Alleviate Burnout in Neurology.Annals of neurology · 2026Review
- Elucidating White Matter Contributions to the Cognitive Architecture of Affective Prosody Recognition: Evidence from Right Hemisphere Stroke.Brain sciences · 2025Article
- Social cognitive function in stroke survivors: A scoping review.Cerebral circulation - cognition and behavior · 2025Review
- Stimulation-based compassion mapping to assess risk of insular resection for surgical epilepsy management: illustrative case.Journal of neurosurgery. Case lessons · 2024Article
- Right hemisphere stroke is linked to reduced social connectedness in the UK Biobank cohort.Scientific reports · 2024Article
- Altered empathy processing in frontotemporal dementia A task-based fMRI study.bioRxiv : the preprint server for biology · 2024Article
- Neural correlates of altered emotional responsivity to infant stimuli in mothers who use substances.Journal of psychiatric research · 2024Article
- Loss of empathy in stroke.Frontiers in psychology · 2024Article
- Article
- Deep-learning-enabled brain hemodynamic mapping using resting-state fMRI.NPJ digital medicine · 2023Article
- Association of inferior division MCA stroke location with populations with atrial fibrillation incidence.Heliyon · 2023Article
18 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
9 authors at 2 institutions in 1 country.
Funding
Abstract
Functional imaging studies of healthy participants and previous lesion studies have provided evidence that empathy involves dissociable cognitive functions that rely on at least partially distinct neural networks that can be individually impaired by brain damage. These studies converge in support of the proposal that affective empathy--making inferences about how another person feels--engages at least the following areas: prefrontal cortex, orbitofrontal gyrus, anterior insula, anterior cingulate cortex, temporal pole, amygdala and temporoparietal junction. We hypothesized that right-sided lesions to any one of these structures, except temporoparietal junction, would cause impaired affective empathy (whereas bilateral damage to temporoparietal junction would be required to disrupt empathy). We studied 27 patients with acute right hemisphere ischaemic stroke and 24 neurologically intact inpatients on a test of affective empathy. Acute impairment of affective empathy was associated with infarcts in the hypothesized network, particularly temporal pole and anterior insula. All patients with impaired affective empathy were also impaired in comprehension of affective prosody, but many patients with impairments in prosodic comprehension had spared affective empathy. Patients with impaired affective empathy were older, but showed no difference in performance on tests of hemispatial neglect, volume of infarct or sex distribution compared with patients with intact affective empathy.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.