ReviewClinical microbiology reviews2013
Matrix-assisted laser desorption ionization-time of flight mass spectrometry: a fundamental shift in the routine practice of clinical microbiology.
Review in Clinical microbiology reviews, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 365 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
365 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Antimicrobial Efficacy of Nd:YAG Laser in Polymicrobial Root Canal Infections: A Systematic Review of In Vitro Studies.International journal of molecular sciences · 2025Pooled it
- The plaque reducing efficacy of oil pulling with sesame oil: a randomized-controlled clinical study.Clinical oral investigations · 2025Trial
- Comparison of Bruker Biotyper Sirius, VITEK MS PRIME, and ASTA MicroIDSys MALDI-TOF MS Systems forAnnals of laboratory medicine · 2026Article
- Clinical characteristics and antimicrobial susceptibility ofNew microbes and new infections · 2026Article
- Biofilm Dynamics and Antimicrobial Resistance in Rabbit Odontogenic Infections: A One Health Perspective.Pathogens (Basel, Switzerland) · 2026Review
- Evaluation of an adapted relative growth method by MALDI-TOF MS for rapid determination of the susceptibility ofMicrobiology spectrum · 2026Article
- Antimicrobial-resistant Staphylococcus spp. and Mammaliicoccus sciuri isolated from rehabilitating wild mammals in northeastern Brazil: implications for microbiological surveillance and biosafety in wildlife care facilities.Veterinary research communications · 2026Article
- Multisite Colonization Ecology of Multidrug-Resistant and Commensal Bacteria Among Cardiovascular Outpatients: A Cross-Sectional Study from Cairo, Egypt.Antibiotics (Basel, Switzerland) · 2026Article
- Resolution of MALDI-TOF MS compared to whole genome sequencing for the identification of Vibrio parahaemolyticus strains isolated from oysters.Archives of microbiology · 2026Article
- Antimicrobial Resistance Across Four Iraqi Governorates: A Multicenter Cross-Sectional Surveillance Analysis With Implications for Antimicrobial Stewardship Policy and WHO AWaRe-Aligned Public Health Strategies.JMIR public health and surveillance · 2026Article
- Article
- Epidemiological and molecular characterization of multidrug-resistantMicrobiology spectrum · 2026Article
- Evaluating the Autof MS2600 vs. Biotyper Sirius MALDI-TOF MS: a head-to-head study for routine microbial identification in a university clinical microbiology laboratory.European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology · 2026Article
- The current discordance on Serratia spp. taxonomical diagnosis using proteomics or genomic tools.BMC microbiology · 2026Article
- Expired Dialysate, Unexpected Pathogen: First Reported Case of Streptomyces Olivaceus Peritonitis in a Peritoneal Dialysis Patient.Kidney360 · 2026Article
- Antimicrobial Resistance and Biofilm in Bacteria from Rehabilitated Sapajus libidinosus.EcoHealth · 2026Article
- Sessile growth on human dentine is associated withJournal of conservative dentistry and endodontics · 2026Article
- Ultrasonographic Gallbladder Findings and Bile Culture Results in Dogs with Extrahepatic Biliary Disorders: A Retrospective Exploratory Case Series.Life (Basel, Switzerland) · 2026Article
- Effectiveness of hydrogen peroxide fumigation using an automated fogging system for environmental management in educational institutions.Scientific reports · 2026Article
- Evaluation of Matrix-Assisted Laser Desorption/Ionization Time-of-Flight (MALDI-TOF) Mass Spectrometry for Identification of AdultPathogens (Basel, Switzerland) · 2026Article
305 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Within the past decade, clinical microbiology laboratories experienced revolutionary changes in the way in which microorganisms are identified, moving away from slow, traditional microbial identification algorithms toward rapid molecular methods and mass spectrometry (MS). Historically, MS was clinically utilized as a high-complexity method adapted for protein-centered analysis of samples in chemistry and hematology laboratories. Today, matrix-assisted laser desorption ionization-time of flight (MALDI-TOF) MS is adapted for use in microbiology laboratories, where it serves as a paradigm-shifting, rapid, and robust method for accurate microbial identification. Multiple instrument platforms, marketed by well-established manufacturers, are beginning to displace automated phenotypic identification instruments and in some cases genetic sequence-based identification practices. This review summarizes the current position of MALDI-TOF MS in clinical research and in diagnostic clinical microbiology laboratories and serves as a primer to examine the "nuts and bolts" of MALDI-TOF MS, highlighting research associated with sample preparation, spectral analysis, and accuracy. Currently available MALDI-TOF MS hardware and software platforms that support the use of MALDI-TOF with direct and precultured specimens and integration of the technology into the laboratory workflow are also discussed. Finally, this review closes with a prospective view of the future of MALDI-TOF MS in the clinical microbiology laboratory to accelerate diagnosis and microbial identification to improve patient care.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.