Evidence map›Paper›PMID 23824366›Full record

ReviewClinical microbiology reviews2013

Staphylococcal and streptococcal superantigen exotoxins.

Adam R Spaulding, Wilmara Salgado-Pabón, Petra L Kohler, Alexander R Horswill, Donald Y M Leung, Patrick M Schlievert

Open access · bronzeAbstract readReview
In one paragraph

Review in Clinical microbiology reviews, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 272 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
272citing papers in PubMed, 1 pooled it
30.7field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

272 citing papers in PubMed, 1 synthesis or guideline pooled it, 518 citations in OpenAlex.

  1. Pooled it
  2. Trial
  3. Trial
  4. Trial
  5. Review
  6. Article
  7. Article
  8. Selective Expansion of TCR Vβ2Experimental dermatology · 2026
    Article
  9. Article
  10. Materials today. Bio · 2026
    Article
  11. Review
  12. Article
  13. Article
  14. Article
  15. Article
  16. Article
  17. Article
  18. Myopathies in clinical care: a focus on treatable causes.Journal of neural transmission (Vienna, Austria : 1996) · 2026
    Review
  19. Review
  20. Article

212 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 1 country.

Adam R SpauldingDepartment of Microbiology, University of Iowa Carver College of Medicine, Iowa City, Iowa, USA.
Wilmara Salgado-Pabón
Petra L Kohler
Alexander R Horswill
Donald Y M Leung
Patrick M Schlievert
University of Iowa · USUniversity of Colorado Denver · USUniversity of Minnesota Medical Center · US

Funding

Vaccines and Therapies Against BotulismU54AI057153 · NIAID · UNIVERSITY OF CHICAGO · PI CROSSON, SEAN · 2003 to 2013
$87.6M
SEAL (Stopping Atopic dermatitis and ALlergy) Study: Prevent allergy by enhancing the skin barrierU01AI147462 · NIAID · STANFORD UNIVERSITY · PI Mary Johnson, GIDEON LACK · 2020 to 2026
$14.0M
THE ROLE OF BACTERIAL TOXINS IN HUMAN SKIN DISEASER01AR041256 · NIAMS · NATIONAL JEWISH HEALTH · PI GOLEVA, ELENA, LEUNG, DONALD YM · 1992 to 2020
$5.9M
Cardiotoxicity of Streptococcal Pyrogenic ExotoxinsR01AI074283 · NIAID · UNIVERSITY OF MINNESOTA · PI SCHLIEVERT, PATRICK M · 2007 to 2011
$1.6M
NIAID NIH HHS R01 AI074283NIAID NIH HHS U01 AI147462NIAID NIH HHS U54 AI057153NIAID NIH HHS U54 AI57153NIAMS NIH HHS R01 AR041256NIAMS NIH HHS R01 AR41256
6 · The paper itself

Abstract

SUMMARY This review begins with a discussion of the large family of Staphylococcus aureus and beta-hemolytic streptococcal pyrogenic toxin T lymphocyte superantigens from structural and immunobiological perspectives. With this as background, the review then discusses the major known and possible human disease associations with superantigens, including associations with toxic shock syndromes, atopic dermatitis, pneumonia, infective endocarditis, and autoimmune sequelae to streptococcal illnesses. Finally, the review addresses current and possible novel strategies to prevent superantigen production and passive and active immunization strategies.

Indexed as

AnimalsExotoxinsHumansModels, MolecularStaphylococcal InfectionsStaphylococcus aureusStreptococcal InfectionsStreptococcus pyogenesSuperantigensExotoxinsSuperantigens

Identifiers

PMID23824366
PMCPMC3719495
OpenAlexW1980496604

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.