ArticleJournal of psychopharmacology (Oxford, England)2013
Acute serotonin 2A receptor blocking alters the processing of fearful faces in the orbitofrontal cortex and amygdala.
Article in Journal of psychopharmacology (Oxford, England), 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 2 of them syntheses that pooled it.
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Who cites it
16 citing papers in PubMed, 2 syntheses or guidelines pooled it, 27 citations in OpenAlex.
- Facial affect processing deficits in schizophrenia: a meta-analysis of antipsychotic treatment effects.Journal of psychopharmacology (Oxford, England) · 2015Pooled it
- Should perception of emotions be classified according to threat detection rather than emotional valence? An updated meta-analysis for a whole-brain atlas of emotional faces processing.Journal of psychiatry & neuroscience : JPNPooled it
- Functional brain responses to emotional faces after three to five weeks of intake of escitalopram in healthy individuals: a double-blind, placebo-controlled randomised study.Scientific reports · 2024Trial
- Role of emotional processing in depressive responses to sex-hormone manipulation: a pharmacological fMRI study.Translational psychiatry · 2015Trial
- Fluctuations in [¹¹C]SB207145 PET binding associated with change in threat-related amygdala reactivity in humans.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2015Trial
- Generalizable structure-function covariation predictive of antidepressant response revealed by target-oriented multimodal fusion.Nature. Mental health · 2026Article
- The 'PSILAUT' protocol: an experimental medicine study of autistic differences in the function of brain serotonin targets of psilocybin.BMC psychiatry · 2024Article
- Amygdala response to emotional faces following acute administration of psilocybin in healthy individuals.Neuroscience applied · 2024Article
- Anxiety and depression: A top-down, bottom-up model of circuit function.Annals of the New York Academy of Sciences · 2023Review
- Elevated levels of serotonin 5-HTEuropean archives of psychiatry and clinical neuroscience · 2023Article
- Neuroticism predicts the impact of serotonin challenges on fear processing in subgenual anterior cingulate cortex.Scientific reports · 2018Article
- Serotonin 2A Receptor Signaling Underlies LSD-induced Alteration of the Neural Response to Dynamic Changes in Music.Cerebral cortex (New York, N.Y. : 1991) · 2018Article
- Functional Characterization of 5-HTThe Journal of neuroscience : the official journal of the Society for Neuroscience · 2017Article
- Threat-related amygdala functional connectivity is associated with 5-HTTLPR genotype and neuroticism.Social cognitive and affective neuroscience · 2016Article
- 5-HTTLPR differentially predicts brain network responses to emotional faces.Human brain mapping · 2015Article
- Targeting Serotonin 5-HTAggression and violent behaviorArticle
Corrections and comments
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Authors and funding
7 authors at 4 institutions in 2 countries.
Funding
Abstract
backgroundThe serotonin 2A (5-HT2A) receptor has been implicated in neural-processing of emotionally salient information. To elucidate its role in processing of fear and anger, healthy individuals were studied with functional magnetic resonance imaging (fMRI) after 5-HT2A receptor blockade, while judging the gender of neutral, fearful and angry faces.
methods5-HT2A receptors were blocked with ketanserin to a variable degree across subjects by adjusting the time between ketanserin-infusion and onset of the fMRI protocol. Neocortical 5-HT2A receptor binding in terms of the binding potential (BPp ) was assessed prior to fMRI with (18)F-altanserin positron emission tomography (PET) and subsequently integrated in the fMRI data analysis. Also functional connectivity analysis was employed to evaluate the effect of ketanserin blocking on connectivity.
resultsCompared to a control session, 5-HT2A receptor blockade reduced the neural response to fearful faces in the medial orbitofrontal cortex (OFC), independently of 5-HT2A receptor occupancy or neocortical 5-HT2A receptor BPp . The medial OFC also showed increased functional coupling with the left amygdala during processing of fearful faces depending on the amount of blocked 5-HT2A receptors.
conclusions5-HT2A receptor mediated signaling increases the sensitivity of the OFC to fearful facial expressions and regulates the strength of a negative feedback signal from the OFC to amygdala during processing of fearful faces.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.