ArticleAnnals of biomedical engineering2013
Near infrared spectroscopic evaluation of water in hyaline cartilage.
Article in Annals of biomedical engineering, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 38 papers.
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Who cites it
38 citing papers in PubMed.
- Visible and near-infrared spectroscopic method for correlative joint tissue analysis and visual and histologic grading.MethodsX · 2026Article
- Repeatability of SimultaneousNMR in biomedicine · 2026Article
- Near-infrared spectroscopy for moisture content prediction in soil-mixed woody biomass.Scientific reports · 2026Article
- Key roles of the superficial zone in articular cartilage physiology, pathology, and regeneration.Chinese medical journal · 2025Review
- Serum vascular endothelial growth factor affects tissue fluid accumulation and is associated with deteriorating tissue perfusion and oxygenation in severe sepsis: a prospective observational study.European journal of medical research · 2023Observational
- Diffuse reflectance spectroscopy of the cartilage tissue in the fourth optical window.Biomedical optics express · 2023Article
- Are Citric Acid-Iron II Complexes True Chelates or Just Physical Mixtures and How to Prove This?Foods (Basel, Switzerland) · 2023Article
- Intraoperative hyperspectral imaging (HSI) as a new diagnostic tool for the detection of cartilage degeneration.Scientific reports · 2022Article
- Raman spectroscopy-based water measurements identify the origin of MRI T2 signal in human articular cartilage zones and predict histopathologic score.Journal of biophotonics · 2022Article
- Article
- Near infrared spectroscopic evaluation of biochemical and crimp properties of knee joint ligaments and patellar tendon.PloS one · 2022Article
- Resolving the Near-Infrared Spectrum of Articular Cartilage.Cartilage · 2021Article
- Compressed sensing time-resolved spectrometer for quantification of light absorbers in turbid media.Biomedical optics express · 2021Article
- Articular cartilage optical properties in the near-infrared (NIR) spectral range vary with depth and tissue integrity.Biomedical optics express · 2021Article
- Applications of Vibrational Spectroscopy for Analysis of Connective Tissues.Molecules (Basel, Switzerland) · 2021Review
- Characterization of connective tissues using near-infrared spectroscopy and imaging.Nature protocols · 2021Article
- Near Infrared Spectroscopy Enables Differentiation of Mechanically and Enzymatically Induced Cartilage Injuries.Annals of biomedical engineering · 2020Article
- Machine Learning Classification of Articular Cartilage Integrity Using Near Infrared Spectroscopy.Cellular and molecular bioengineering · 2020Article
- Near infrared spectroscopic assessment of loosely and tightly bound cortical bone water.The Analyst · 2020Article
- Approaches forTissue engineering. Part C, Methods · 2020Article
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Authors and funding
3 authors.
Funding
Abstract
In diseased conditions of cartilage such as osteoarthritis, there is typically an increase in water content from the average normal of 60-85% to greater than 90%. As cartilage has very little capability for self-repair, methods of early detection of degeneration are required, and assessment of water could prove to be a useful diagnostic method. Current assessment methods are either destructive, time consuming, or have limited sensitivity. Here, we investigated the hypotheses that non-destructive near infrared spectroscopy (NIRS) of articular cartilage can be used to differentiate between free and bound water, and to quantitatively assess water content. The absorbances centered at 5200 and 6890 cm(-1) were attributed to a combination of free and bound water, and to free water only, respectively. The integrated areas of both absorbance bands were found to correlate linearly with the absolute water content (R = 0.87 and 0.86) and with percent water content (R = 0.97 and 0.96) of the tissue. Partial least square models were also successfully developed and were used to predict water content, and percent free water. These data demonstrate that NIRS can be utilized to quantitatively determine water content in articular cartilage, and may aid in early detection of degenerative tissue changes in a laboratory setting, and with additional validations, possibly in a clinical setting.
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