ArticleNucleus (Austin, Tex.)
A polymer model explains the complexity of large-scale chromatin folding.
Article in Nucleus (Austin, Tex.). The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed.
- Review
- DNA-Topology Simplification by Topoisomerases.Molecules (Basel, Switzerland) · 2021Review
- Dynamic Crowding Regulates Transcription.Biophysical journal · 2020Article
- Polymer Modeling Predicts Chromosome Reorganization in Senescence.Cell reports · 2019Article
- Chromosome territories and the global regulation of the genome.Genes, chromosomes & cancer · 2019Review
- Forces driving the three-dimensional folding of eukaryotic genomes.Molecular systems biology · 2018Review
- Gene functioning and storage within a folded genome.Cellular & molecular biology letters · 2017Review
- The Shh Topological Domain Facilitates the Action of Remote Enhancers by Reducing the Effects of Genomic Distances.Developmental cell · 2016Article
- Nucleosomal arrays self-assemble into supramolecular globular structures lacking 30-nm fibers.The EMBO journal · 2016Article
- Large-scale probabilistic 3D organization of human chromosome territories.Human molecular genetics · 2016Article
- Distinct polymer physics principles govern chromatin dynamics in mouse and Drosophila topological domains.BMC genomics · 2015Article
- The clustering of CpG islands may constitute an important determinant of the 3D organization of interphase chromosomes.Epigenetics · 2014Article
- Reprogramming of fibroblast nuclei in cloned bovine embryos involves major structural remodeling with both striking similarities and differences to nuclear phenotypes of in vitro fertilized embryos.Nucleus (Austin, Tex.) · 2014Article
- Inferring Spatial Organization of Individual Topologically Associated Domains via Piecewise Helical Model.IEEE/ACM transactions on computational biology and bioinformaticsArticle
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Authors and funding
7 authors.
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Abstract
The underlying global organization of chromatin within the cell nucleus has been the focus of intense recent research. Hi-C methods have allowed for the detection of genome-wide chromatin interactions, revealing a complex large-scale organization where chromosomes tend to partition into megabase-sized "topological domains" of local chromatin interactions and intra-chromosomal contacts extends over much longer scales, in a cell-type and chromosome specific manner. Until recently, the distinct chromatin folding properties observed experimentally have been difficult to explain in a single conceptual framework. We reported that a simple polymer-physics model of chromatin, the strings and binders switch (SBS) model, succeeds in describing the full range of chromatin configurations observed in vivo. The SBS model simulates the interactions between randomly diffusing binding molecules and binding sites on a polymer chain. It explains how polymer architectural patterns can be established, how different stable conformations can be produced and how conformational changes can be reliably regulated by simple strategies, such as protein upregulation or epigenetic modifications, via fundamental thermodynamics mechanisms.
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