ArticlePloS one2013
The Observation of Highly Ordered Domains in Membranes with Cholesterol.
Article in PloS one, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 45 papers.
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Who cites it
45 citing papers in PubMed.
- Cis glycan-glycan interactions organize membrane nanodomains that tune receptor signaling.Nature communications · 2026Article
- Encapsulants Affect Liposome Surface Interactions with Biological Systems.Small (Weinheim an der Bergstrasse, Germany) · 2025Article
- Phase Behavior of Binary Mixtures of SOPC and Cholesterol.ACS omega · 2025Review
- Understanding the coarse-grained free energy landscape of phospholipids and their phase separation.Biophysical journal · 2025Article
- A Label-Free Multitechnique Approach to Characterize the Interaction of Bioactive Compounds with Biomimetic Interfaces.Small science · 2024Article
- Melatonin: Regulation of Prion Protein Phase Separation in Cancer Multidrug Resistance.Molecules (Basel, Switzerland) · 2022Review
- Article
- Structural and mechanical properties of the red blood cell's cytoplasmic membrane seen through the lens of biophysics.Frontiers in physiology · 2022Review
- Effects of cholesterol on the size distribution and bending modulus of lipid vesicles.PloS one · 2022Article
- Melatonin: Regulation of Biomolecular Condensates in Neurodegenerative Disorders.Antioxidants (Basel, Switzerland) · 2021Review
- Capturing Membrane Phase Separation by Dual Resolution Molecular Dynamics Simulations.Journal of chemical theory and computation · 2021Article
- Recent developments in the kinetics of ruptures of giant vesicles under constant tension.RSC advances · 2021Review
- EPA and DHA differentially modulate membrane elasticity in the presence of cholesterol.Biophysical journal · 2021Article
- Blood bank storage of red blood cells increases RBC cytoplasmic membrane order and bending rigidity.PloS one · 2021Article
- Effects of osmotic pressure on the irreversible electroporation in giant lipid vesicles.PloS one · 2021Article
- Laterally Resolved Small-Angle Scattering Intensity from Lipid Bilayer Simulations: An Exact and a Limited-Range Treatment.Journal of chemical theory and computation · 2020Article
- Influence of cholesterol on electroporation in lipid membranes of giant vesicles.European biophysics journal : EBJ · 2020Article
- Functional lipid pairs as building blocks of phase-separated membranes.Proceedings of the National Academy of Sciences of the United States of America · 2020Article
- Modelling of interactions between Aβ(25-35) peptide and phospholipid bilayers: effects of cholesterol and lipid saturation.RSC advances · 2020Article
- Glucose Can Protect Membranes against Dehydration Damage by Inducing a Glassy Membrane State at Low Hydrations.Membranes · 2019Article
Corrections and comments
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Authors and funding
9 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Rafts, or functional domains, are transient nano- or mesoscopic structures in the exoplasmic leaflet of the plasma membrane, and are thought to be essential for many cellular processes. Using neutron diffraction and computer modelling, we present evidence for the existence of highly ordered lipid domains in the cholesterol-rich (32.5 mol%) liquid-ordered ([Formula: see text]) phase of dipalmitoylphosphatidylcholine membranes. The liquid ordered phase in one-component lipid membranes has previously been thought to be a homogeneous phase. The presence of highly ordered lipid domains embedded in a disordered lipid matrix implies non-uniform distribution of cholesterol between the two phases. The experimental results are in excellent agreement with recent computer simulations of DPPC/cholesterol complexes [Meinhardt, Vink and Schmid (2013). Proc Natl Acad Sci USA 110(12): 4476-4481], which reported the existence of nanometer size [Formula: see text] domains in a liquid disordered lipid environment.
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