ArticlePloS one2013
Transgenic Tobacco Overexpressing Tea cDNA Encoding Dihydroflavonol 4-Reductase and Anthocyanidin Reductase Induces Early Flowering and Provides Biotic Stress Tolerance.
Article in PloS one, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
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Who cites it
26 citing papers in PubMed, 40 citations in OpenAlex.
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- A review of flavonoids at the crossroads of plant defense: integrating biotic and abiotic stress tolerance through AI- and CRISPR/Cas-guided metabolic reprogramming.Frontiers in plant science · 2026Review
- Influencing Factors and Regulatory Mechanisms of Fresh Tea Leaf Quality: A Review.Foods (Basel, Switzerland) · 2025Review
- Overexpression of thePlant signaling & behavior · 2023Article
- Antioxidants of Non-Enzymatic Nature: Their Function in Higher Plant Cells and the Ways of Boosting Their Biosynthesis.Antioxidants (Basel, Switzerland) · 2023Review
- Effects of editing DFR genes on flowers, leaves, and roots of tobacco.BMC plant biology · 2023Article
- Enhancing alfalfa resistance to Spodoptera herbivory by sequestering microRNA396 expression.Plant cell reports · 2023Article
- Integrated transcriptome and microRNA sequencing analyses reveal gene responses in poplar leaves infected by the novel pathogen bean common mosaic virus (BCMV).Frontiers in plant science · 2023Article
- Isolation and functional diversification of dihydroflavonol 4-Reductase genePlant signaling & behavior · 2022Article
- BSA‑seq and genetic mapping reveals AhRt2 as a candidate gene responsible for red testa of peanut.TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik · 2022Review
- Functional Analysis of GenesBioMed research international · 2022Article
- Transgenic tobacco plant overexpressing ginkgo dihydroflavonol 4-reductase geneFrontiers in plant science · 2022Article
- Overexpression of dihydroflavonol 4-reductase (Frontiers in plant science · 2022Article
- Genome-Wide Identification and Characterization of Short-Chain Dehydrogenase/Reductase (SDR) Gene Family inInternational journal of molecular sciences · 2021Article
- Advances in Biosynthesis and Biological Functions of Proanthocyanidins in Horticultural Plants.Foods (Basel, Switzerland) · 2020Review
- Article
- Identification of the vernalization gene VRN-B1 responsible for heading date variation by QTL mapping using a RIL population in wheat.BMC plant biology · 2020Article
- Article
- Comprehensive analysis of putative dihydroflavonol 4-reductase gene family in tea plant.PloS one · 2019Article
- Dissection of Chemical Composition and Associated Gene Expression in the Pigment-Deficient Tea Cultivar 'Xiaoxueya' Reveals an Albino Phenotype and Metabolite Formation.Frontiers in plant science · 2019Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Flavan-3-ols contribute significantly to flavonoid content of tea (Camellia sinensis L.). Dihydroflavonol 4-reductase (DFR) and anthocyanidin reductase (ANR) are known to be key regulatory enzymes of flavan-3-ols biosynthesis. In this study, we have generated the transgenic tobacco overexpressing individually tea cDNA CsDFR and CsANR encoding for DFR and ANR to evaluate their influence on developmental and protective abilities of plant against biotic stress. The transgenic lines of CsDFR and CsANR produced early flowering and better seed yield. Both types of transgenic tobacco showed higher content of flavonoids than control. Flavan-3-ols such as catechin, epicatechin and epicatechingallate were found to be increased in transgenic lines. The free radical scavenging activity of CsDFR and CsANR transgenic lines was improved. Oxidative stress was observed to induce lesser cell death in transgenic lines compared to control tobacco plants. Transgenic tobacco overexpressing CsDFR and CsANR also showed resistance against infestation by a tobacco leaf cutworm Spodoptera litura. Results suggested that the overexpression of CsDFR and CsANR cDNA in tobacco has improved flavonoids content and antioxidant potential. These attributes in transgenic tobacco have ultimately improved their growth and development, and biotic stress tolerance.
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