ArticleCell metabolism2013
Cold exposure promotes atherosclerotic plaque growth and instability via UCP1-dependent lipolysis.
Article in Cell metabolism, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 116 papers.
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Who cites it
116 citing papers in PubMed, 229 citations in OpenAlex.
- Statins Reduce Epicardial Adipose Tissue Attenuation Independent of Lipid Lowering: A Potential Pleiotropic Effect.Journal of the American Heart Association · 2019Trial
- Thermogenic adipocytes promote HDL turnover and reverse cholesterol transport.Nature communications · 2017Trial
- Review
- Exercise-induced adipose tissue ADRB2-PGC1α-FGF21 signaling protects against pathological cardiac hypertrophy.iScience · 2026Article
- Cold exposure aggravates vein occlusion through non-shivering thermogenesis-induced thrombocytopoiesis.Cell research · 2026Article
- UCP1-Dependent Thermogenic Adipose Tissue in Human Disease: Adipose-Centered Mechanisms, Biomarker Limitations, and Translational Perspectives.International journal of molecular sciences · 2026Review
- Cold exposure-induced loss of beneficial gut bacterial sEV is associated with the pathogenesis of bone loss through pyroptosis pathway.Journal of nanobiotechnology · 2026Article
- Gut microbiota-associated leucine elevation promotes cold-induced atherosclerotic plaque formation and instability.Journal of translational medicine · 2026Article
- Adipocytes influence choroidal neovascularization via PRDM16.EMBO molecular medicine · 2026Article
- Cold exposure increases aortic dissection risk through extracellular cold inducible RNA binding protein and toll like receptor 4 signaling.Scientific reports · 2026Article
- Integrating multi-omics and deep learning to explore the active ingredients and molecular mechanisms ofFrontiers in pharmacology · 2026Article
- Seasonal changes in lipid profiles and homocysteine in patients with and without coronary heart disease: a real-world paired retrospective study in a cold-climate region.Frontiers in cardiovascular medicine · 2026Article
- Incidence, prevalence, and global burden of myocarditis among individuals aged 65 and older from 1990 to 2021 across 204 countries: a critical re-analysis of data from the global burden of disease study.Frontiers in cardiovascular medicine · 2026Article
- From endocrine to immune: therapeutic potential of brown adipose tissue in remodelling the cardiovascular immune microenvironment.Frontiers in immunology · 2026Review
- Brown adipose tissue activation and cardiovascular risk following PD-1 antibody therapy in cancer patients: a retrospective cohort study.European journal of medical research · 2025Article
- Brown and beige adipose tissue-derived metabokine and lipokine inter-organ signalling in health and disease.Experimental physiology · 2025Review
- Mechanism of cold exposure delaying wound healing in mice.Journal of nanobiotechnology · 2024Article
- Keys to the switch of fat burning: stimuli that trigger the uncoupling protein 1 (UCP1) activation in adipose tissue.Lipids in health and disease · 2024Review
- Seasonal variability of lesions distribution in acute ischemic stroke: A retrospective study.Scientific reports · 2024Article
- [Activation ofNan fang yi ke da xue xue bao = Journal of Southern Medical University · 2024Article
56 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
18 authors at 5 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Molecular mechanisms underlying the cold-associated high cardiovascular risk remain unknown. Here, we show that the cold-triggered food-intake-independent lipolysis significantly increased plasma levels of small low-density lipoprotein (LDL) remnants, leading to accelerated development of atherosclerotic lesions in mice. In two genetic mouse knockout models (apolipoprotein E(-/-) [ApoE(-/-)] and LDL receptor(-/-) [Ldlr(-/-)] mice), persistent cold exposure stimulated atherosclerotic plaque growth by increasing lipid deposition. Furthermore, marked increase of inflammatory cells and plaque-associated microvessels were detected in the cold-acclimated ApoE(-/-) and Ldlr(-/-) mice, leading to plaque instability. Deletion of uncoupling protein 1 (UCP1), a key mitochondrial protein involved in thermogenesis in brown adipose tissue (BAT), in the ApoE(-/-) strain completely protected mice from the cold-induced atherosclerotic lesions. Cold acclimation markedly reduced plasma levels of adiponectin, and systemic delivery of adiponectin protected ApoE(-/-) mice from plaque development. These findings provide mechanistic insights on low-temperature-associated cardiovascular risks.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.