ArticleCell metabolism2013
Sweet nothings: sensing of sugar metabolites controls T cell function.
Article in Cell metabolism, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
2 citing papers in PubMed, 5 citations in OpenAlex.
- Rethinking the paradigm: How comparative studies on fatty acid oxidation inform our understanding of T cell metabolism.Molecular immunology · 2015Review
- l-Arginine depletion blunts antitumor T-cell responses by inducing myeloid-derived suppressor cells.Cancer research · 2015Article
Corrections and comments
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Authors and funding
2 authors at 2 institutions in 1 country.
Funding
Abstract
Signal transduction and metabolism cooperate to control cell fate, but mechanisms that link metabolic substrates to functional decisions are elusive. Now, Chang et al. (2013) in Cell provide a mechanism whereby available sugars dictate metabolic pathways in activated T cells and direct a nonmetabolic regulatory function of glyceraldehyde-3-phosphate dehydrogenase.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.