ArticleScientific reports2013
High-speed atomic force microscopy combined with inverted optical microscopy for studying cellular events.
Article in Scientific reports, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers.
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Who cites it
35 citing papers in PubMed, 97 citations in OpenAlex.
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- Enhanced visualization of influenza A virus entry into living cells using virus-view atomic force microscopy.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Nano-Scale Video Imaging of Motility Machinery by High-Speed Atomic Force Microscopy.Biomolecules · 2025Review
- Machine learning-guided reconstruction of cytoskeleton network from live-cell AFM images.iScience · 2024Article
- An open-source combined atomic force microscope and optical microscope for mechanobiology studies.Heliyon · 2024Article
- Technical advances in high-speed atomic force microscopy.Biophysical reviews · 2023Review
- Chemo-mechanical forces modulate the topology dynamics of mesoscale DNA assemblies.Nature communications · 2023Article
- Morphometric and Nanomechanical Screening of Peripheral Blood Cells with Atomic Force Microscopy for Label-Free Assessment of Alzheimer's Disease, Parkinson's Disease, and Amyotrophic Lateral Sclerosis.International journal of molecular sciences · 2023Review
- Multi-Reconfigurable DNA Origami Nanolattice Driven by the Combination of Orthogonal Signals.JACS Au · 2023Article
- Hybridization of papain molecules and DNA-wrapped single-walled carbon nanotubes evaluated by atomic force microscopy in fluids.Scientific reports · 2023Article
- Algorithmic Design of 3D Wireframe RNA Polyhedra.ACS nano · 2022Article
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- Structural variability and dynamics in the ectodomain of an ancestral-type classical cadherin revealed by AFM imaging.Journal of cell science · 2021Article
- An ultra-wide scanner for large-area high-speed atomic force microscopy with megapixel resolution.Scientific reports · 2021Article
- Measuring collagen fibril diameter with differential interference contrast microscopy.Journal of structural biology · 2021Article
- Chemo-Mechanical Modulation of Cell Motions Using DNA Nanosprings.Bioconjugate chemistry · 2021Article
- Design and Fabrication of a High-Speed Atomic Force Microscope Scan-Head.Sensors (Basel, Switzerland) · 2021Article
- High-speed force spectroscopy: microsecond force measurements using ultrashort cantilevers.Biophysical reviews · 2019Review
Corrections and comments
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Authors and funding
9 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
A hybrid atomic force microscopy (AFM)-optical fluorescence microscopy is a powerful tool for investigating cellular morphologies and events. However, the slow data acquisition rates of the conventional AFM unit of the hybrid system limit the visualization of structural changes during cellular events. Therefore, high-speed AFM units equipped with an optical/fluorescence detection device have been a long-standing wish. Here we describe the implementation of high-speed AFM coupled with an optical fluorescence microscope. This was accomplished by developing a tip-scanning system, instead of a sample-scanning system, which operates on an inverted optical microscope. This novel device enabled the acquisition of high-speed AFM images of morphological changes in individual cells. Using this instrument, we conducted structural studies of living HeLa and 3T3 fibroblast cell surfaces. The improved time resolution allowed us to image dynamic cellular events.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.