Evidence map›Paper›PMID 23823329›Full record

Trial reportInternational journal of obesity (2005)2014

Weight loss, exercise or both and cardiometabolic risk factors in obese older adults: results of a randomized controlled trial.

M Bouchonville, R Armamento-Villareal, K Shah, N Napoli, D R Sinacore, C Qualls, D T Villareal

Registry-linked trialAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in International journal of obesity (2005), 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06592209 (Body Electric), which is not on this map. Cited by 90 papers, 20 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
90citing papers in PubMed, 20 pooled it
8.8field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06592209 nacompletednot on this mapstarted 2023, after this paper: background citation

Body Electric: a Pragmatic Trial Evaluating Movement Breaks As a Public Health Strategy to Mitigate the Harms of Prolonged Sedentary Behavior

TypeinterventionalSponsorColumbia UniversityRan2023 to 2023Enrolled20,217ConditionsSedentary BehaviorArmsSedentary Breaks
3 · Its place in the literature

Who cites it

90 citing papers in PubMed, 20 syntheses or guidelines pooled it, 154 citations in OpenAlex.

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  10. Impact of different training modalities on anthropometric outcomes in patients with obesity: A systematic review and network meta-analysis.Obesity reviews : an official journal of the International Association for the Study of Obesity · 2021
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  11. Long-term effects of weight-reducing diets in people with hypertension.The Cochrane database of systematic reviews · 2021
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  14. Treatment of Diabetes in Older Adults: An Endocrine Society* Clinical Practice Guideline.The Journal of clinical endocrinology and metabolism · 2019
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  19. Long-term effects of weight-reducing diets in people with hypertension.The Cochrane database of systematic reviews · 2016
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30 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 4 institutions in 2 countries.

M BouchonvilleDivsion of Endocrinology, Diabetes, and Metabolism, University of New Mexico School of Medicine, Albuquerque, NM, USA.
R Armamento-Villareal1] Divsion of Endocrinology, Diabetes, and Metabolism, University of New Mexico School of Medicine, Albuquerque, NM, USA [2] Section of Endocrinology, New Mexico Veterans Affairs Health Care System, Albuquerque, NM, USA.
K ShahDivision of Geriatrics and Aging, University of Rochester School of Medicine, Rochester, NY, USA.
N NapoliDivision of Endocrinology, University Campus Bio-Medico Di Roma, Rome, Italy.
D R Sinacore1] Division of Geriatrics and Nutritional Science, Washington University School of Medicine, St Louis, MO, USA [2] Program in Physical Therapy, Washington University School of Medicine, St Louis, MO, USA.
C QuallsDepartment of Mathematics and Statistics, University of New Mexico School of Medicine, Albuquerque, NM, USA.
D T Villareal1] Division of Geriatrics and Nutritional Science, Washington University School of Medicine, St Louis, MO, USA [2] Division of Geriatrics, University of New Mexico School of Medicine, Albuquerque, NM, USA [3] Section of Geriatrics, New Mexico VA Health Care System, Albuquerque, NM, USA.
University of New Mexico · USWashington University in St. Louis · USUniversità Campus Bio-Medico · ITUniversity of Rochester · US

Funding

Washington University Institute of Clinical and Translational Sciences (UL1)UL1RR024992 · NCRR · WASHINGTON UNIVERSITY · PI EVANOFF, BRADLEY A · 2007 to 2011
$45.4M
Washington University Institute of Clinical and Translational SciencesUL1TR000448 · NCATS · WASHINGTON UNIVERSITY · PI EVANOFF, BRADLEY A · 2012 to 2016
$41.4M
Washington University Nutrition Obesity Research CenterP30DK056341 · NIDDK · WASHINGTON UNIVERSITY · PI Dominic N Reeds · 1999 to 2026
$30.2M
WU P&FP30DK020579 · NIDDK · WASHINGTON UNIVERSITY · PI Clay F. Semenkovich · 2013 to 2026
$27.1M
TRANSGENICS COREP60DK020579 · NIDDK · WASHINGTON UNIVERSITY · PI SCHAFFER, JEAN E. · 1986 to 2012
$25.2M
EXERCISE INTERVENTIONS DURING VOLUNTARY WEIGHT LOSS IN OBESE OLDER ADULTSR01AG031176 · NIA · WASHINGTON UNIVERSITY · PI VILLAREAL, DENNIS T. · 2009 to 2016
$2.3M
Weight Loss and Exercise in Frail Obese Elderly SubjectsR01AG025501 · NIA · WASHINGTON UNIVERSITY · PI VILLAREAL, DENNIS T. · 2005 to 2009
$1.7M
NCATS NIH HHS UL1 TR000448NCRR NIH HHS UL1 RR024992NCRR NIH HHS UL1-RR024992NIA NIH HHS R01 AG025501NIA NIH HHS R01-AG025501NIA NIH HHS R01 AG031176NIA NIH HHS R01-AG031176NIDDK NIH HHS DK20579NIDDK NIH HHS P30 DK020579NIDDK NIH HHS P30 DK056341NIDDK NIH HHS P30-DK56341NIDDK NIH HHS P60 DK020579
6 · The paper itself

Abstract

backgroundObesity exacerbates the age-related decline in insulin sensitivity and is associated with risk for cardiometabolic syndrome in older adults; however, the appropriate treatment for obese older adults is controversial.

objectiveTo determine the independent and combined effects of weight loss and exercise on cardiometabolic risk factors in obese older adults.

designOne-hundred and seven obese (body mass index (BMI)≥30 kg m(-2)) older (≥65 years) adults with physical frailty were randomized to control group, diet group, exercise group and diet-exercise group for 1 year. Outcomes for this study included changes in insulin sensitivity index (ISI), glucose tolerance, central obesity, adipocytokines and cardiometabolic syndrome.

resultsAlthough similar increases in ISI occurred in the diet-exercise and diet groups at 6 months, the ISI improved more in the diet-exercise than in the diet group at 12 months (2.4 vs 1.2; between-group difference, 1.2; 95% confidence interval, 0.2-2.1); no changes in ISI occurred in both exercise and control groups. The diet-exercise and diet groups had similar improvements in insulin area under the curve (AUC) (-2.9 and -2.9 × 10(3) mg min dl(-1)), glucose AUC (-1.4 and -2.2 × 10(3)mg min dl(-1)), visceral fat (-787 and -561 cm(3)), tumor necrosis factor (-17.0 and -12.8 pg ml(-1)), adiponectin (5.0 and 4.0 ng ml(-1)), waist circumference (-8.2 and -8.4 cm), triglyceride (-30.7 and -24.3 g dl(-1)) and systolic/diastolic blood pressure (-15.9 and -13.1/-4.9 and -6.7 mm Hg), while no changes in these parameters occurred in both exercise and control groups. The cardiometabolic syndrome prevalence decreased by 40% in the diet-exercise and by 15% in the diet group. Body weight decreased similarly in the diet-exercise and diet groups (-8.6 and -9.7 kg) but not in the exercise and control groups.

conclusionsIn frail, obese older adults, lifestyle interventions associated with weight loss improve insulin sensitivity and other cardiometabolic risk factors, but continued improvement in insulin sensitivity is only achieved when exercise training is added to weight loss.

Indexed as

Diet, ReducingExerciseWeight LossAdiponectinAgedBlood GlucoseBlood PressureBody WeightCardiovascular DiseasesCombined Modality TherapyC-Reactive ProteinDietFemaleGlucose Tolerance TestHumansIntra-Abdominal FatAdiponectinBlood GlucoseC-Reactive Protein

Identifiers

PMID23823329
PMCPMC3835728
OpenAlexW2028846462

What OpenQuestion holds

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LicenceTDM
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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.