ArticleBiophysical journal2013
Complex patterns of metabolic and Ca²⁺ entrainment in pancreatic islets by oscillatory glucose.
Article in Biophysical journal, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed.
- Diabetes-associated genetic variation in TCF7L2 alters pulsatile insulin secretion in humans.JCI insight · 2020Trial
- Glucose-driven intra- and inter-islet beta cell synchronization in pancreatic tissue slices.Scientific reports · 2026Article
- CaAmerican journal of physiology. Endocrinology and metabolism · 2023Review
- Optimal phase-selective entrainment of heterogeneous oscillator ensembles.SIAM journal on applied dynamical systems · 2023Article
- Islet-on-a-chip for the study of pancreatic β-cell function.In vitro models · 2022Review
- From Isles of Königsberg to Islets of Langerhans: Examining the Function of the Endocrine Pancreas Through Network Science.Frontiers in endocrinology · 2022Review
- Fluidics system for resolving concentration-dependent effects of dissolved gases on tissue metabolism.eLife · 2021Article
- The effects of beta-cell mass and function, intercellular coupling, and islet synchrony on [Formula: see text] dynamics.Scientific reports · 2021Article
- Article
- Heterogeneity and Delayed Activation as Hallmarks of Self-Organization and Criticality in Excitable Tissue.Frontiers in physiology · 2019Article
- Critical and Supercritical Spatiotemporal Calcium Dynamics in Beta Cells.Frontiers in physiology · 2017Article
- Phase modulation of insulin pulses enhances glucose regulation and enables inter-islet synchronization.PloS one · 2017Article
- Article
- Dual Detection System for Simultaneous Measurement of Intracellular Fluorescent Markers and Cellular Secretion.Analytical chemistry · 2016Article
- Glucose Oscillations Can Activate an Endogenous Oscillator in Pancreatic Islets.PLoS computational biology · 2016Article
- Modelling chronotaxicity of cellular energy metabolism to facilitate the identification of altered metabolic states.Scientific reports · 2016Article
- Measurement of the entrainment window of islets of Langerhans by microfluidic delivery of a chirped glucose waveform.Integrative biology : quantitative biosciences from nano to macro · 2015Article
- Integrated perfusion and separation systems for entrainment of insulin secretion from islets of Langerhans.Lab on a chip · 2015Article
- Optimal entrainment of heterogeneous noisy neurons.Frontiers in neuroscience · 2015Article
- An energy-optimal approach for entrainment of uncertain circadian oscillators.Biophysical journal · 2014Article
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4 authors.
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Abstract
Glucose-stimulated insulin secretion is pulsatile and driven by intrinsic oscillations in metabolism, electrical activity, and Ca(2+) in pancreatic islets. Periodic variations in glucose can entrain islet Ca(2+) and insulin secretion, possibly promoting interislet synchronization. Here, we used fluorescence microscopy to demonstrate that glucose oscillations can induce distinct 1:1 and 1:2 entrainment of oscillations (one and two oscillations for each period of exogenous stimulus, respectively) in islet Ca(2+), NAD(P)H, and mitochondrial membrane potential. To our knowledge, this is the first demonstration of metabolic entrainment in islets, and we found that entrainment of metabolic oscillations requires voltage-gated Ca(2+) influx. We identified diverse patterns of 1:2 entrainment and showed that islet synchronization during entrainment involves adjustments of both oscillatory phase and period. All experimental findings could be recapitulated by our recently developed mathematical model, and simulations suggested that interislet variability in 1:2 entrainment patterns reflects differences in their glucose sensitivity. Finally, our simulations and recordings showed that a heterogeneous group of islets synchronized during 1:2 entrainment, resulting in a clear oscillatory response from the collective. In summary, we demonstrate that oscillatory glucose can induce complex modes of entrainment of metabolically driven oscillations in islets, and provide additional support for the notion that entrainment promotes interislet synchrony in the pancreas.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.