ArticlePloS one2013
Voltage-Gated Lipid Ion Channels.
Article in PloS one, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed.
- High-frequency signals: a comparison between the cable equation and telegrapher's equations in nerves.BMC biomedical engineering · 2025Article
- Multiple conductance states of lipid pores during Voltage-Clamp electroporation.Bioelectrochemistry (Amsterdam, Netherlands) · 2023Article
- Bio-Mimicking, Electrical Excitability Phenomena Associated With Synthetic Macromolecular Systems: A Brief Review With Connections to the Cytoskeleton and Membraneless Organelles.Frontiers in molecular neuroscience · 2022Review
- The Effect of Cholesterol on the Voltage-Current Characteristics of Tethered Lipid Membranes.The Journal of membrane biology · 2020Article
- Non-linear Conductance, Rectification, and Mechanosensitive Channel Formation of Lipid Membranes.Frontiers in cell and developmental biology · 2020Article
- A thermodynamic description for physiological transmembrane transport.F1000Research · 2018Article
- Article
- Mechanical surface waves accompany action potential propagation.Nature communications · 2015Article
- Protein reconstitution into freestanding planar lipid membranes for electrophysiological characterization.Nature protocols · 2015Article
- The thermodynamics of general and local anesthesia.Biophysical journal · 2014Article
Corrections and comments
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Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Synthetic lipid membranes can display channel-like ion conduction events even in the absence of proteins. We show here that these events are voltage-gated with a quadratic voltage dependence as expected from electrostatic theory of capacitors. To this end, we recorded channel traces and current histograms in patch-experiments on lipid membranes. We derived a theoretical current-voltage relationship for pores in lipid membranes that describes the experimental data very well when assuming an asymmetric membrane. We determined the equilibrium constant between closed and open state and the open probability as a function of voltage. The voltage-dependence of the lipid pores is found comparable to that of protein channels. Lifetime distributions of open and closed events indicate that the channel open distribution does not follow exponential statistics but rather power law behavior for long open times.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.