ArticleJournal of applied physiology (Bethesda, Md. : 1985)2014
Sex and vasodilator responses to hypoxia at rest and during exercise.
Article in Journal of applied physiology (Bethesda, Md. : 1985), 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
33 citing papers in PubMed, 53 citations in OpenAlex.
- β-Adrenergic receptors mediate sex differences in vasodilation but not sympathetic-mediated vasoconstriction during hypoxia.American journal of physiology. Heart and circulatory physiology · 2025Trial
- Alterations in acid-base balance and high-intensity exercise performance after short-term and long-term exposure to acute normobaric hypoxic conditions.Scientific reports · 2020Trial
- Effects of losartan and allopurinol on cardiorespiratory regulation in obstructive sleep apnoea.Experimental physiology · 2018Trial
- Acute dietary nitrate supplementation enhances compensatory vasodilation during hypoxic exercise in older adults.Journal of applied physiology (Bethesda, Md. : 1985) · 2015Trial
- Sex-related differences in the peripheral vascular response to hypoxia: Implications in health and relevance for obstructive sleep apnoea.Experimental physiology · 2026Review
- The effect of sex on the isolated and combined α- and β-adrenergic control of blood flow during handgrip in adults at high altitude: An exploratory study.Physiological reports · 2026Article
- Sex-differences in Mountain Ultra-trail Performance: Look at the Scenery.Sports medicine - open · 2025Article
- Role of overweight and obesity on vascular responses to the cold pressor test and hypoxia in women.Journal of applied physiology (Bethesda, Md. : 1985) · 2025Article
- Recommendations for Women in Mountain Sports and Hypoxia Training/Conditioning.Sports medicine (Auckland, N.Z.) · 2024Review
- Women at Altitude: Sex-Related Physiological Responses to Exercise in Hypoxia.Sports medicine (Auckland, N.Z.) · 2024Review
- Quadriceps fatigue during hypoxic and ischemic knee-extension exercise is similar in males and females.Journal of applied physiology (Bethesda, Md. : 1985) · 2024Article
- The forearm vascular response to sympathetic activation is attenuated in female, but not male, participants following acute intermittent hypoxia.Journal of applied physiology (Bethesda, Md. : 1985) · 2023Article
- Combining hypoxia with thermal stimuli in humans: physiological responses and potential sex differences.American journal of physiology. Regulatory, integrative and comparative physiology · 2023Review
- Adrenergic control of skeletal muscle blood flow during chronic hypoxia in healthy males.American journal of physiology. Regulatory, integrative and comparative physiology · 2023Article
- On the haemodynamic consequence of the chemoreflex and muscle mechanoreflex interaction in women and men: two tales, one story.The Journal of physiology · 2022Article
- Influence and Mechanisms of Action of Environmental Stimuli on Work Near and Above the Severe Domain Boundary (Critical Power).Sports medicine - open · 2022Review
- Sympathetic neurovascular transduction following acute hypoxia.Clinical autonomic research : official journal of the Clinical Autonomic Research Society · 2021Article
- Sex differences in the vascular response to sympathetic activation during acute hypoxaemia.Experimental physiology · 2021Article
- Sex differences in integrated neurocardiovascular control of blood pressure following acute intermittent hypercapnic hypoxia.American journal of physiology. Regulatory, integrative and comparative physiology · 2020Article
- Assessment of resistance vessel function in human skeletal muscle: guidelines for experimental design, Doppler ultrasound, and pharmacology.American journal of physiology. Heart and circulatory physiology · 2020Review
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 1 country.
Funding
Abstract
In humans, β-adrenergic receptor activation causes a substantial portion of hypoxic vasodilation in skeletal muscle at rest and during forearm exercise. Recent evidence suggests that β-adrenergic receptors are either more sensitive or upregulated in young women vs. men. Therefore, we examined whether sex influences hypoxic vasodilation in 31 young subjects (15 women/16 men; 26 ± 1 yr). We also examined whether potential sex-related differences existed in a group of older adults (6 women/5 men; 61 ± 2 yr). All subjects performed forearm exercise at 10 and 20% of maximum under normoxic and hypoxic [80% arterial O2 saturation (So2)] conditions. Forearm vascular conductance (FVC; ml · min(-1) · 100 mmHg(-1)) was calculated from blood flow (ml/min) and blood pressure (mmHg). At rest, young women demonstrated a greater vasodilator response to hypoxia compared with men (39 ± 12 vs. 13 ± 6%, P < 0.05). The absolute compensatory vasodilator response (hypoxic FVC-normoxic FVC) during exercise was similar between sexes, but the relative change was greater in young women at 10% (28 ± 5 vs. 17 ± 3%, P < 0.05) and 20% exercise (29 ± 4% vs. 15 ± 3%, P < 0.01). Additionally, the absolute changes in vasodilation after normalizing the response to forearm volume or workload were greater in young women during exercise (P < 0.05). Interestingly, the compensatory vasodilator responses between older women and men were similar at 10 and 20% exercise, regardless of whether the response is expressed as absolute, relative, or absolute change normalized for forearm volume or workload (P = 0.054-0.97). Our data suggest that the compensatory vasodilator response to hypoxic exercise is greater in young women compared with men. However, sex-specific differences appear to be lost with aging.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.