Evidence map›Paper›PMID 23823139›Full record

ArticleAmerican journal of Alzheimer's disease and other dementias2014

Magnetic Resonance Spectroscopy Study of Amnestic Mild Cognitive Impairment and Vascular Cognitive Impairment With No Dementia.

Yan-Yan Liu, Zhong-Xian Yang, Zhi-Wei Shen, Ye-Yu Xiao, Xiao-Fang Cheng, Wei Chen, Yao-Wen Chen, Ren-Hua Wu

Open access · greenAbstract readComparative Study
PubMed Full text at PMC Publisher
In one paragraph

Article in American journal of Alzheimer's disease and other dementias, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed, 1 pooled it
0.6field-weighted citation impact, top 30% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 1 synthesis or guideline pooled it, 10 citations in OpenAlex.

  1. Pooled it
  2. Review
  3. Article
  4. Article
  5. Review
  6. Article
  7. Recent research about mild cognitive impairment in China.Shanghai archives of psychiatry · 2014
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Yan-Yan LiuDepartment of Medical Imaging Center, the Second Affiliated Hospital, Medical College of Shantou University, Shantou, China.
Zhong-Xian YangDepartment of Medical Imaging Center, the Second Affiliated Hospital, Medical College of Shantou University, Shantou, China.
Zhi-Wei ShenDepartment of Medical Imaging Center, the Second Affiliated Hospital, Medical College of Shantou University, Shantou, China.
Ye-Yu XiaoDepartment of Medical Imaging Center, the Second Affiliated Hospital, Medical College of Shantou University, Shantou, China.
Xiao-Fang ChengDepartment of Medical Imaging Center, the Second Affiliated Hospital, Medical College of Shantou University, Shantou, China.
Wei ChenDepartment of Neurology, the Second Affiliated Hospital, Medical College of Shantou University, Shantou, China.
Yao-Wen ChenDepartment of Medical Imaging Center, the Second Affiliated Hospital, Medical College of Shantou University, Shantou, China.
Ren-Hua WuDepartment of Medical Imaging Center, the Second Affiliated Hospital, Medical College of Shantou University, Shantou, China Provincial Key Laboratory of Medical Molecular Imaging, Guangdong, Shantou, China rhwu@stu.edu.cn.
Second Affiliated Hospital of Shantou University Medical College · CNShantou University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Amnestic mild cognitive impairment (aMCI) and vascular cognitive impairment with no dementia (VCIND) are highly predictive of Alzheimer's disease and vascular dementia. In this study, a 2-dimensional magnetic resonance spectroscopy was performed in 25 patients with aMCI, 28 patients with VCIND, and 32 normal controls (NCs). The concentrations of N-acetyl aspartate (NAA), choline (Cho), myoinositol (MI), and creatine (Cr) were measured, and their ratios were calculated. The patients with aMCI displayed significantly lower NAA/MI bilaterally in the posterior cingulate gyrus (PCG) and white matter of occipital lobe (OLWM) than NC participants or patients with VCIND , whereas patients with VCIND displayed markedly lower NAA/Cho bilaterally in the white matter of frontal lobe (FLWM) and left OLWM, and right dorsal thalamus (DT) than patients with NC or aMCI. Compared with the controls, patients with aMCI displayed lower NAA and NAA/Cr in bilateral PCG, left precuneus, and DT, whereas patients with VCIND displayed lower NAA/Cr in bilateral DT and FLWM. In addition, increased MI in right PCG of patients with aMCI and increased Cho in left FLWM of patients with VCIND were also observed. The results might help guide a clinical differentiation between the 2 disorders.

Indexed as

AgedAmnesiaCerebrovascular DisordersCognition DisordersCognitive DysfunctionFemaleHumansMagnetic Resonance SpectroscopyMaleMiddle Agedamnesic mild cognitive impairmentMR spectroscopyvascular cognitive impairment with no dementia

Identifiers

PMID23823139
PMCPMC10852712
OpenAlexW2324986827

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.