ArticleMobile DNA2013
The Putzig partners DREF, TRF2 and KEN are involved in the regulation of the Drosophila telomere retrotransposons, HeT-A and TART.
Article in Mobile DNA, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed, 16 citations in OpenAlex.
- Multiple Roles of dXNP and dADD1-International journal of molecular sciences · 2023Review
- Identification of theCells · 2022Article
- Stonewall prevents expression of ectopic genes in the ovary and accumulates at insulator elements in D. melanogaster.PLoS genetics · 2022Article
- DREF Genetically Counteracts Mi-2 and Caf1 to Regulate Adult Stem Cell Maintenance.PLoS genetics · 2019Article
- dAdd1 and dXNP prevent genome instability by maintaining HP1a localization at Drosophila telomeres.Chromosoma · 2017Article
- Drosophila: Retrotransposons Making up Telomeres.Viruses · 2017Review
- Widespread colocalization of the Drosophila histone acetyltransferase homolog MYST5 with DREF and insulator proteins at active genes.Chromosoma · 2017Article
- Telomeric repeat silencing in germ cells is essential for early development in Drosophila.Nucleic acids research · 2015Article
- Loss of putzig Activity Results in Apoptosis during Wing Imaginal Development in Drosophila.PloS one · 2015Article
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Authors and funding
3 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundTelomere maintenance in Drosophila relies on the targeted transposition of three very special non-LTR retrotransposons, HeT-A, TART, and TAHRE (HTT). The sequences of the retrotransposon array build up the telomere chromatin in this organism. We have recently reported the role of the chromosomal protein Putzig/Z4 in maintaining a proper chromatin structure at the telomere domain of Drosophila. Because the Putzig protein has been found in different cellular complexes related with cell proliferation, development, and immunity, we decided to investigate whether the previously described Putzig partners, DREF/TRF2 and KEN, could also be involved in the telomere function in this organism.
resultsWe have found that mutant alleles for Dref/Trf2 and Ken show alterations in HeT-A and TART expression, suggesting a possible role of these protein complexes in the regulation of the telomere retrotransposons. In agreement, both HeT-A and TART contain the specific DNA binding sequences for the DREF and the KEN protein proteins.
conclusionsWe have identified three new negative regulators involved in the control of the expression of the telomeric retrotransposons, Dref, Trf2, and Ken. Our results offer some clues on which other chromatin-related proteins might be involved in telomere regulation and retrotransposon control.
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