ArticleJournal of medicinal food2013
Protective effect of Pinus koraiensis needle water extract against oxidative stress in HepG2 cells and obese mice.
Article in Journal of medicinal food, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed, 19 citations in OpenAlex.
- The Impact ofNutrients · 2024Trial
- Insight into the Hypoglycemic Effects ofPlants (Basel, Switzerland) · 2026Article
- Anti-Obesity and Weight Management-Related Antioxidant Potential Properties of Calabrian Pine Extracts:Plants (Basel, Switzerland) · 2025Article
- Anti-Obesity Effect of Pine Needle Extract on High-Fat Diet-Induced Obese Mice.Plants (Basel, Switzerland) · 2021Article
- Effects of the Appropriate Addition of Antioxidants fromAnimals : an open access journal from MDPI · 2020Article
- Pine ( Pinus densiflora ) needle extract could promote the expression of PCNA and Ki-67 after partial hepatectomy in rat.Acta cirurgica brasileira · 2019Article
- Evaluation of the Effects of Pinus koraiensis Needle Extracts on Serum Lipid and Oxidative Stress in Adults with Borderline Dyslipidemia: A Randomized, Double-Blind, and Placebo-Controlled Clinical Trial.Evidence-based complementary and alternative medicine : eCAM · 2016Article
- Selectivity of Pinus sylvestris extract and essential oil to estrogen-insensitive breast cancer cells Pinus sylvestris against cancer cells.Pharmacognosy magazine · 2015Article
- Antioxidant and antiapoptotic effects of pine needle powder ingestion and endurance training in high cholesterol-fed rats.Journal of exercise nutrition & biochemistry · 2014Article
Corrections and comments
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Authors and funding
6 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Needles of pine species are rich in polyphenols, which may exert beneficial effects on human health. The present study was conducted to evaluate the in vitro and in vivo antioxidant effects of Pinus koraiensis needle water extracts (PKW). HepG2 cells were pretreated with various concentrations of PKW (from 10(-3) to 1 mg/mL) and oxidative stress was induced by tert-butyl hydroperoxide (t-BOOH). In the animal model, male ICR mice were fed a high-fat diet for 6 weeks to induce obesity, and then mice were continually fed a high-fat diet with or without orally administered PKW (400 mg/kg body weight) for 5 weeks. Pretreatment with PKW prevented significant increases in cytotoxicity and catalase activity induced by t-BOOH in HepG2 cells. Similarly, the catalase protein expression levels elevated by t-BOOH were abrogated in cells pretreated with PKW. In mice fed a high-fat diet, PKW significantly increased hepatic activities of catalase and glutathione reductase and lower lipid peroxidation levels were observed in the liver and kidney of mice with PKW supplementation. The present study demonstrates that PKW protects against oxidative stress in HepG2 cells treated with t-BOOH and in mice fed a high-fat diet.
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