ArticleOrganic letters2013
Deconvoluting the reactivity of two intermediates formed from modified pyrimidines.
Article in Organic letters, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
10 citing papers in PubMed.
- Photo-Reactivity of Binaphthalene Triphenylphosphonium Salts: DNA Interstrand Cross-Link Formation and Substituent Effects.Chemical research in toxicology · 2022Article
- Spatial and Temporal Resolution of the Oxygen-Independent Photoinduced DNA Interstrand Cross-Linking by a Nitroimidazole Derivative.Journal of chemical information and modeling · 2022Article
- Traceless Tandem Lesion Formation in DNA from a Nitrogen-Centered Purine Radical.Journal of the American Chemical Society · 2018Article
- Independent Generation and Reactivity of Thymidine Radical Cations.The Journal of organic chemistry · 2017Article
- Pyrimidine Nucleobase Radical Reactivity in DNA and RNA.Radiation physics and chemistry (Oxford, England : 1993) · 2016Article
- Photochemical Generation of Benzyl Cations That Selectively Cross-Link Guanine and Cytosine in DNA.Organic letters · 2016Article
- Reactivity of Nucleic Acid Radicals.Advances in physical organic chemistry · 2016Article
- Bromopyridone Nucleotide Analogues, Anoxic Selective Radiosensitizing Agents That Are Incorporated in DNA by Polymerases.The Journal of organic chemistry · 2015Article
- Interstrand cross-link and bioconjugate formation in RNA from a modified nucleotide.The Journal of organic chemistry · 2014Article
- DNA interstrand cross-linking upon irradiation of aryl halide C-nucleotides.The Journal of organic chemistry · 2014Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
Abstract
Generation of the 5-(2'-deoxyuridinyl)methyl radical (6) was reexamined. Trapping by 4-hydroxy-2,2,6,6-tetramethylpiperidin-1-oxyl confirms that 6 is generated. However, trapping by methoxyamine reveals that the respective carbocation (10) is also produced. Examining the effects of these traps on products in DNA reveals that the carbocation and not 6 yields interstrand cross-links. Cross-link formation from the carbocation is consistent with DFT calculations that predict that addition at the N1 position of dA is essentially barrierless.
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Registered trials
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