ArticleProceedings of the National Academy of Sciences of the United States of America2013
Solid-phase peptide synthesis and solid-phase fragment coupling mediated by isonitriles.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
5 citing papers in PubMed.
- Total Chemical Synthesis and Folding of All-l and All-d Variants of Oncogenic KRas(G12V).Journal of the American Chemical Society · 2017Article
- Fully Synthetic Granulocyte Colony-Stimulating Factor Enabled by Isonitrile-Mediated Coupling of Large, Side-Chain-Unprotected Peptides.Journal of the American Chemical Society · 2015Article
- Combining triazole ligation and enzymatic glycosylation on solid phase simplifies the synthesis of very long glycoprotein analogues.Chemical science · 2015Article
- Umpolung amide synthesis using substoichiometric N-iodosuccinimide (NIS) and oxygen as a terminal oxidant.Organic letters · 2014Article
- Erythropoietin derived by chemical synthesis.Science (New York, N.Y.) · 2013Article
Corrections and comments
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Authors and funding
2 authors.
Funding
Abstract
The synthesis of polypeptides on solid phase via mediation by isonitriles is described. The acyl donor is a thioacid, which presumably reacts with the isonitrile to generate a thio-formimidate carboxylate mixed anhydride intermediate. Applications of this chemistry to reiterative solid-phase peptide synthesis as well as solid-phase fragment coupling are described.
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Registered trials
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