ArticleG3 (Bethesda, Md.)2013
Genetic determinants of cell size at birth and their impact on cell cycle progression in Saccharomyces cerevisiae.
Article in G3 (Bethesda, Md.), 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 1 of them a synthesis that pooled it.
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Who cites it
15 citing papers in PubMed, 1 synthesis or guideline pooled it.
- The cellular growth rate controls overall mRNA turnover, and modulates either transcription or degradation rates of particular gene regulons.Nucleic acids research · 2016Pooled it
- uORF-mediated translational control of CAK and Cdk activation in response to low nutrients in yeast.EMBO reports · 2026Article
- Translational control of CAK and Cdk T-loop phosphorylation in response to growth in yeast.bioRxiv : the preprint server for biology · 2026Article
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- Abundances of transcripts, proteins, and metabolites in the cell cycle of budding yeast reveal coordinate control of lipid metabolism.Molecular biology of the cell · 2020Article
- Perturbations of Transcription and Gene Expression-Associated Processes Alter Distribution of Cell Size Values inG3 (Bethesda, Md.) · 2019Article
- Article
- Asymmetric cell division requires specific mechanisms for adjusting global transcription.Nucleic acids research · 2017Article
- Editing of misaminoacylated tRNA controls the sensitivity of amino acid stress responses in Saccharomyces cerevisiae.Nucleic acids research · 2017Article
- Translational control of lipogenic enzymes in the cell cycle of synchronous, growing yeast cells.The EMBO journal · 2017Article
- Article
- Enhanced longevity by ibuprofen, conserved in multiple species, occurs in yeast through inhibition of tryptophan import.PLoS genetics · 2014Article
- Systematic identification of cell size regulators in budding yeast.Molecular systems biology · 2014Article
- Multiple metabolic requirements for size homeostasis and initiation of division inMicrobial cell (Graz, Austria) · 2014Article
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Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In most cases, cells must increase their size before they can divide. Hence, a small size has been used often as a phenotype for mutants that accelerate initiation of division, such as the celebrated WHI mutants of budding yeast. Recently, we measured the DNA content of all nonessential gene deletion strains in Saccharomyces cerevisiae. Surprisingly, there was little, if any, correlation between mean cell size and cell-cycle progression. Here, we examine this issue further, providing the first systematic analysis of genetic determinants of the cell size at birth. We found that although a large birth size strongly correlates with a large mean size, the converse relationship (i.e., small birth size vs. small mean size) is not as strong. Our data also suggest that mutants that are born large do not have a significant advantage for faster cell-cycle progression. In contrast, mutants that are born small are more likely to progress slower in the cell cycle. The majority of gene deletions that displayed such phenotypes affect protein synthesis or ribosome biogenesis. Overall, our data suggest that birth size may be a more informative parameter for cell-cycle progression than the mean size of a proliferating cell population. In contrast to WHI phenotype expectations, a small size is more likely to be associated with delayed cell-cycle progression.
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