Evidence map›Paper›PMID 23821023›Full record

ArticleEuropean radiology2013

Correlation of contrast-enhanced ultrasound kinetics with prognostic factors in invasive breast cancer.

Botond K Szabó, Ariel Saracco, Ervin Tánczos, Peter Aspelin, Karin Leifland, Brigitte Wilczek, Rimma Axelsson

Abstract readEvaluation Study
PubMed Publisher
In one paragraph

Article in European radiology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed.

  1. Review
  2. Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. Contrast-Enhanced Ultrasound Imaging of Breast Masses: Adjunct Tool to Decrease the Number of False-Positive Biopsy Results.Journal of ultrasound in medicine : official journal of the American Institute of Ultrasound in Medicine · 2019
    Article
  10. Article
  11. Article
  12. Article
  13. Article
  14. Article
  15. Article
  16. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Botond K SzabóDepartment of Radiology, Faculty of Medicine, University of Szeged, 6725, Szeged, Semmelweis u. 6., Hungary, raeszabb@gmail.com.
Ariel Saracco
Ervin Tánczos
Peter Aspelin
Karin Leifland
Brigitte Wilczek
Rimma Axelsson

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectivesTo correlate contrast-enhanced ultrasound (CEUS) kinetic parameters with traditional and molecular prognostic factors in invasive breast cancer.

methodsSeventy-five invasive breast cancers were evaluated with contrast harmonic imaging after the injection of a bolus dose of 2.4 ml sulphur hexafluoride microbubble contrast agent. The lognormal function was used for quantitative analysis of kinetic data. These parameters correlated with traditional prognostic factors (tumour size, histological type, tumour grade, axillary lymph node status) and immunohistochemical biomarkers (ER, PR and HER2 status).

resultsStatistically significant correlation was found between time-to-peak and tumour grade (P value  =  0.023), PR status (P value =  0.042) and axillary node status (P value  =  0.025). Wash-out ratio, measured at 21 s was significantly associated with ER status (P value  =  0.042) and PR status (P value  =  0.026).

conclusionsInvasive breast carcinomas exhibiting earlier peak enhancement and faster elimination of microbubble contrast agent at CEUS are found to be associated with established predictors of poor prognosis.

Indexed as

Sulfur HexafluorideAdenocarcinomaAdenocarcinoma, MucinousAdultAgedAged, 80 and overArea Under CurveAxillaBiopsyBreast NeoplasmsCarcinoma, DuctalCarcinoma, PapillaryContrast MediaFemaleHumansImage EnhancementContrast MediaSulfur Hexafluoride

Identifiers

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.