ArticleLasers in medical science2014
The role of transforming growth factor β1 in fractional laser resurfacing with a carbon dioxide laser.
Article in Lasers in medical science, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 34 citations in OpenAlex.
- Fractional carbon dioxide laser for the treatment of facial atrophic acne scars: prospective clinical trial with short and long-term evaluation.Lasers in medical science · 2017Trial
- Therapeutic Effect of Topical Triamcinolone Acetonide Combined With 10600-nm Ablative Fractional Carbon Dioxide Laser or 1565-nm Non-Ablative Fractional Laser on Hypertrophic Scars in the Rabbit Ear Model.Aesthetic plastic surgery · 2026Article
- Skinspan: A Holistic Roadmap for Extending Skin Longevity With Evidence-Based Interventions.Journal of cosmetic dermatology · 2025Review
- Platelet-rich plasma as an adjuvant therapy to fractional ablative carbon dioxide lasers for cutaneous repair: a complementary treatment for atrophic acne scarring.Lasers in medical science · 2024Review
- Bacterial nanocellulose/calcium alginate hydrogel for the treatment of burns.Acta cirurgica brasileira · 2024Article
- Microcurrent and Gold Nanoparticles Combined with Hyaluronic Acid Accelerates Wound Healing.Antioxidants (Basel, Switzerland) · 2022Article
- Efficacy and Safety of Ablative Fractional Laser-Assisted Delivery of Methotrexate in Adults with Localized Scleroderma: A Randomized and Controlled Clinical Trial.Pharmaceutics · 2022Article
- Transcriptomic analysis of human skin wound healing and rejuvenation following ablative fractional laser treatment.PloS one · 2021Article
- Efficacy of Fractional Carbon Dioxide Laser in the Treatment of Mature Burn Scars: A Clinical, Histopathological, and Histochemical Study.The Journal of clinical and aesthetic dermatology · 2017Article
- Nevus spilus: treatment with fractional COLasers in medical science · 2017Article
- A Low-Level Carbon Dioxide Laser Promotes Fibroblast Proliferation and Migration through Activation of Akt, ERK, and JNK.PloS one · 2017Article
- Improvement of Microstomia in Scleroderma after Carbon Dioxide Laser Treatment.Case reports in dermatologyArticle
- COTherapeutic advances in urologyReview
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The aim of this study was to investigate the role of transforming growth factor β1 in mechanisms of cutaneous remodeling induced by fractional carbon dioxide laser treatment. The dorsal skin of Kunming mice was exposed to a single-pass fractional CO2 laser treatment. Biopsies were taken at 1 h and at 1, 3, 7, 14, 21, 28, and 56 days after treatment. Transforming growth factor (TGF) β1 expression in skin samples was evaluated by ELISA, dermal thickness by hematoxylin-eosin staining, collagen and elastic fibers by Ponceau S and Victoria blue double staining, and types I and III collagens by ELISA. The level of TGF β1 in the laser-treated areas of skin was significantly increased compared with that in the control areas on days 1 (p < 0.05), 3 (p < 0.01), and 7 (p < 0.05) and then decreased by day 14 after treatment, at which time it had returned to the baseline level. Dermal thickness and the amount of type I collagen of the skin of the laser-treated areas had increased significantly (p < 0.05) compared with that in control areas on days 28 and 56. Fibroblast proliferation showed a positive correlation with TGF β1 expression during the early stages (r = 0.789, p < 0.01), and there was a negative correlation between the level of TGF β1 and type I collagen in the late stages, after laser treatment (r = -0.546, p < 0.05). TGF β1 appears to be an important factor in fractional laser resurfacing.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.